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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A SARS-coronovirus 3CL protease inhibitor isolated from the marine sponge Axinella cf. corrugata: structure elucidation and synthesis

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Author(s):
Simone P. de Lira [1] ; Mirna H. R. Seleghim [2] ; David E. Williams [3] ; Frederic Marion ; Pamela Hamill [5] ; François Jean [6] ; Raymond J. Andersen ; Eduardo Hajdu [8] ; Roberto G. S. Berlinck [9]
Total Authors: 9
Affiliation:
[1] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[2] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[3] University of British Columbia. Department of Chemistry
[5] University of British Columbia. Life Sciences Centre. Department of Microbiology and Immunology - Canadá
[6] University of British Columbia. Life Sciences Centre. Department of Microbiology and Immunology - Canadá
[8] Universidade Federal do Rio de Janeiro. Museu Nacional - Brasil
[9] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
Total Affiliations: 9
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 18, n. 2, p. 440-443, 2007-04-00.
Abstract

Two coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and esculetin-4-carboxylic acid ethyl ester (2), have been isolated from the marine sponge Axinella cf. corrugata. Structure determination included analysis of spectroscopic data and total synthesis of compound 2. These are the first coumarin derivatives isolated from a marine sponge. The ethyl ester 2 was found to be an in vitro inhibitor of SARS 3CL-protease and an effective inhibitor of SARS-CoV replication in Vero cells at non-cytotoxic concentrations. (AU)

FAPESP's process: 01/03095-5 - Natural products from marine invertebrates: potential chemotherapic anti-proliferative, antibiotic and against tropical diseases agents
Grantee:Roberto Gomes de Souza Berlinck
Support type: Research Projects - Thematic Grants