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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chromosome Instability in Carcinomas

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Paulo Pimentel de Assumpção ; Aline Damasceno Seabra ; Mariana Ferreira Leal ; Adriana Costa Guimarães ; Danielle Queiroz Calcagno ; André Salim Khayat ; Marilia de Arruda Cardoso Smith ; Rommel Rodriguez Burbano
Total Authors: 8
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MORPHOLOGY; v. 24, n. 3, p. 335-338, Set. 2006.

In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumor cells that allows the increase of mutations is named genetic instability, encompassing two mechanisms: microsatellite instability, characterized by nucleotide alterations with errors in the DNA repair systems; and chromosomal instability, represented by aberrations occurring in large chromosome segments. Carcinomas are characterized by complex cytogenetic alterations and large gene amalgamations. Telomeric alterations, inadequately repaired DNA breaks, and deficiencies in the mitotic spindle checking systems are events capable of generating the chromosomal instability and aneuploidy which characterize more aggressive neoplasias. A better understanding of the chromosomal instability mechanisms can show the way towards a clinical utilization of such information, like developing more adequate therapeutic strategies, targeted at specific sites involved in the malignization process (AU)

FAPESP's process: 03/06540-5 - Genetic polymorphisms in aging and comparative genome hybridization (CGH) in gastric neoplasms of the Pará State individuals
Grantee:Marilia de Arruda Cardoso Smith
Support type: Regular Research Grants