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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

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Author(s):
Pimentel, Gustavo D. [1] ; Lira, Fabio S. [1] ; Rosa, Jose C. [1] ; Caris, Aline V. [1] ; Pinheiro, Fernanda [1] ; Ribeiro, Eliane B. [1] ; Oller do Nascimento, Claudia M. [1] ; Oyama, Lila M. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, UNIFESP EPM, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 24, n. 5, p. 809-818, MAY 2013.
Web of Science Citations: 29
Abstract

To clarify the effects of natural dietary components on the metabolic consequences of obesity, we examined the effects of yerba mate extract Ilex paraguariensis on both central and peripheral inflammatory effects of diet-induced obesity and correlated the hypothalamic tumor necrosis factor (TNF)-alpha level with adipose depot weight. Wistar rats were divided into four groups: a control group (CTL) fed with chow diet, a second group fed with chow diet plus yerba mate extract (CTL+E), a third group fed with a high-fat diet rich in saturated fatty acids (HFD) and a fourth group fed with HFD plus yerba mate extract (HFD+E). Enzyme-linked immunosorbent assay, Western blotting, colorimetric method and treatment by gavage were utilized as materials and methods. The HFD groups showed a significant increase in food intake (kcal), body weight, adipose tissue and leptin level in comparison to CTL and CTL+E. HFD leads to increase of both central and peripheral inflammatory effects, and deregulation of insulin pathway. In addition, yerba mate extract intake blunted the proinflammatory effects of diet-induced obesity in rats by reducing the phosphorylation of hypothalamic IKK and NFKBp65 expression and increasing the protein levels of IKBoe, the expression of adiponectin receptor-1 and consequently the amount of IRS-2. Moreover, the increase in interleukin (IL)-6 levels in the liver and muscle and of the IL-10/TNF-alpha ratio in groups that received yerba mate extract showed the anti-inflammatory effects of this natural substance. Taken together, our data suggest that the use of yerba mate extract may be useful for reducing low-grade obesity-associated inflammation. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/14373-8 - Effect of epigallocatechin-gallate on adipokine secretion and TLR4 and NF-kB signalling in adipocytes: in vivo and in vitro study
Grantee:Lila Missae Oyama
Support Opportunities: Regular Research Grants
FAPESP's process: 09/11398-0 - Effect of yerba mate extract Ilex paraguariensis on lipid profile and glucose tolerance on hyperlipidic diet-treated rats
Grantee:Aline Venticinque Caris
Support Opportunities: Scholarships in Brazil - Scientific Initiation