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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum beta-Lactamases in Klebsiella pneumoniae

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Bueno, Maria Fernanda C. [1, 2] ; Francisco, Gabriela R. [1, 2] ; O'Hara, Jessica A. [1] ; Garcia, Doroti de Oliveira [2] ; Doi, Yohei [1]
Total Authors: 5
[1] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA 15260 - USA
[2] Adolfo Lutz Inst, Enter Dis & Infect Special Pathogens Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Antimicrobial Agents and Chemotherapy; v. 57, n. 5, p. 2397-2400, MAY 2013.
Web of Science Citations: 53

Eight Klebsiella pneumoniae clinical strains with high-level aminoglycoside resistance were collected from eight hospitals in Sao Paulo State, Brazil, in 2010 and 2011. Three of them produced an RmtD group 16S rRNA methyltransferase, RmtD1 or RmtD2. Five strains were found to produce a novel 16S rRNA methyltransferase, designated RmtG, which shared 57 to 58% amino acid identity with RmtD1 and RmtD2. Seven strains coproduced KPC-2 with or without various CTX-M group extended-spectrum beta-lactamases, while the remaining strain coproduced CTX-M-2. (AU)

FAPESP's process: 12/06827-1 - Characterization of antimicrobial resistance genes in KPC-producing Klebsiella pneumoniae isolated from several hospitals of São Paulo State, Brazil
Grantee:Maria Fernanda Campagnari Bueno
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/53229-0 - Detection of antimicrobial resistance genes in Klebsiella pneumoniae isolated from nosocomial infection or colonization from several hospitals of São Paulo State, Brazil
Grantee:Doroti de Oliveira Garcia
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)