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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

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Author(s):
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Ota, Vanessa K. [1, 2] ; Gadelha, Ary [3, 2] ; Assuncao, Idaiane B. [2] ; Santoro, Marcos L. [1, 2] ; Christofolini, Denise M. [4] ; Bellucco, Fernanda T. [1] ; Santos-Filho, Airton F. [3] ; Ottoni, Gustavo L. [5] ; Lara, Diogo R. [5] ; Mari, Jair J. [3] ; Melaragno, Maria I. [1] ; Smith, Marilia A. C. [1] ; Bressan, Rodrigo A. [3, 2] ; Belangero, Sintia I. [1, 3, 2] ; Jackowski, Andrea P. [3, 2]
Total Authors: 15
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo - Brazil
[4] FMABC, Dept Obstet & Ginecol, Disciplina Genet & Reprod Humana, Sao Paulo - Brazil
[5] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Porto Alegre, RS - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCHIZOPHRENIA RESEARCH; v. 145, n. 1-3, p. 33-35, APR 2013.
Web of Science Citations: 9
Abstract

ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved. (AU)

FAPESP's process: 11/00030-1 - Association study of endocannabinoid system and schizophrenia
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants