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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rotenone-Dependent Changes of Anterograde Motor Protein Expression and Mitochondrial Mobility in Brain Areas Related to Neurodegenerative Diseases

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Melo, Thaiany Q. [1] ; D'unhao, Aline M. [1] ; Martins, Stephanie A. [1] ; Farizatto, Karen L. G. [1] ; Chaves, Rodrigo S. [1] ; Ferrari, Merari F. R. [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Cellular and Molecular Neurobiology; v. 33, n. 3, p. 327-335, APR 2013.
Web of Science Citations: 8

The presence of protein aggregates is common in neurodegenerative disorders; however, the real cause and effect of these aggregates during neurodegeneration is still a matter of investigation. We hypothesize that impairment of intracellular traffic may appear in the absence of protein inclusions and might trigger protein aggregation. In the present study, we aimed to evaluate mitochondria mobility as well as protein and messenger RNA expression of KIF1B and KIF5 that are molecular motors for neuronal anterograde traffic, in hippocampus, substantia nigra, and locus coeruleus of 10-month-old Lewis rats and cultured cells, from these same areas, following exposure to low doses of rotenone that do not lead to protein inclusions. The present study showed alteration in KIF1B and KIF5 expression, as well as in mitochondria mobility prior to protein aggregation involved in neurodegenerative disorders. These findings suggest that change in intracellular trafficking might be critical and one of the primary events for impairment of cell physiology during neurodegeneration associated with protein inclusions. (AU)

FAPESP's process: 11/05576-2 - Analysis of mitochondrial mobility in living hippocampal, substantia nigra and Locus coeruleus cells before protein aggregation involved in neurodegeneration
Grantee:Stephanie Alves Martins
Support type: Scholarships in Brazil - Master
FAPESP's process: 09/12200-9 - Analysis of RAB protein expression before protein aggregation associated to neurodegeneration
Grantee:Thaiany Quevedo Melo
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/00478-2 - Influence of calcium and MIRO proteins on mitochondrial mobility before and during protein aggregation involved in neurodegeneration
Grantee:Rodrigo dos Santos Chaves
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/06434-7 - Degradation of hyperphosphorylated tau and organelles trafficking during neurodegenerative processes linked to protein aggregation in hypoccampal cell cultures
Grantee:Merari de Fátima Ramires Ferrari
Support type: Regular Research Grants
FAPESP's process: 08/04480-9 - Analysis of intracellular trafficking of mitochondria before protein aggregation formation in neurodegeneration
Grantee:Merari de Fátima Ramires Ferrari
Support type: Regular Research Grants