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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Early immunologic and virologic predictors of clinical HIV-1 disease progression

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Mahnke, Yolanda D. [1] ; Song, Kaimei [1] ; Sauer, Mariana M. [2] ; Nason, Martha C. [3] ; Giret, Maria Teresa M. [2, 4] ; Carvalho, Karina I. [2] ; Costa, Priscilla R. [2] ; Roederer, Mario [1] ; Kallas, Esper G. [2]
Total Authors: 9
[1] NIAID, ImmunoTechnol Sect, VRC, NIH, Bethesda, MD 20892 - USA
[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo - Brazil
[3] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 - USA
[4] Univ Florida, Miller Sch Med, Story Lab 2, Miami, FL - USA
Total Affiliations: 4
Document type: Journal article
Source: AIDS; v. 27, n. 5, p. 697-706, MAR 13 2013.
Web of Science Citations: 7

Objective: To identify early determinants of HIV-1 disease progression, which could potentially enable individualized patient treatment, and provide correlates of progression applicable as reference phenotypes to evaluate breakthrough infections in vaccine development. Design: High-throughput technologies were employed to interrogate multiple parameters on cryopreserved, retrospective peripheral blood mononuclear cell (PBMC) samples from 51 individuals from Sao Paulo, Brazil, obtained within 1 year of diagnosing early Clade B HIV-1 infection. Fast Progressors, Slow Progressors, and Controllers were identified based on a 2-year clinical follow-up. Methods: Phenotypic and functional T-cell parameters were tested by flow cytometry and qPCR to identify potential early determinants of subsequent HIV-1 disease progression. Results: Major differences were observed between Controllers and Progressors, especially in cell-associated viral load (CAVL), the differentiation pattern and CD38 expression of CD8(+) T cells, and the cytokine pattern and activation phenotype of HIV-1-specific CD8(+) T cells. Despite remarkably few other differences between the two Progressor groups, the CAVL had predictive power independent of plasma viral load. Conclusion: Analysis of three parameters (% CD38(+)CD8(+) T cells, total CAVL,% CCR5(+) CD8(+) T cells) was sufficient to predict subsequent disease progression (P < 0.001). Use of such prognostic correlates may be crucial when early CD4(+) T-cell counts and plasma viral load levels fail to discriminate among groups with differing subsequent clinical progression. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins AIDS 2013, 27:697-706 (AU)

FAPESP's process: 06/50096-0 - Characterization of Human Immunodeficiency Virus type 1 (HIV-1) in a cohort of recently infected persons from the State of São Paulo by full genome sequencing
Grantee:Sabri Saeed Mohamed Ahmed Al-Sanabani
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos
Grantee:Ricardo Sobhie Diaz
Support type: Research Projects - Thematic Grants