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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

DNA and histone methylation in gastric carcinogenesis

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Author(s):
Calcagno, Danielle Queiroz [1] ; Gigek, Carolina Oliveira [1] ; Chen, Elizabeth Suchi [1] ; Burbano, Rommel Rodriguez [2] ; Cardoso Smith, Marilia de Arruda [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, BR-04023900 Sao Paulo - Brazil
[2] Fed Univ Para, Lab Human Cytogenet, Inst Biol Sci, BR-66075110 Belem, Para - Brazil
Total Affiliations: 2
Document type: Review article
Source: WORLD JOURNAL OF GASTROENTEROLOGY; v. 19, n. 8, p. 1182-1192, FEB 28 2013.
Web of Science Citations: 54
Abstract

Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. (C) 2013 Baishideng. All rights reserved. (AU)

FAPESP's process: 09/07145-9 - Genetic and epigenetic aspects in gastric carcinogenesis
Grantee:Marilia de Arruda Cardoso Smith
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/11174-1 - Genetic and epigenetic evaluation in gastric cancer
Grantee:Danielle Queiroz Calcagno
Support type: Scholarships in Brazil - Post-Doctorate