ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly

Author(s)

Manzine, Patricia Regina ^[1] ; de Franca Bram, Jessyka Maria ^[1] ; Barham, Elisabeth Joan ^[2] ; Carvalho do Vale, Francisco de Assis ^[3] ; Selistre-de-Araujo, Heloisa Sobreiro ^[4] ; Cominetti, Marcia Regina ^[1] ; Iost Pavarini, Sofia Cristina ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Psicol, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Med, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; v. 35, n. 1-2, p. 58-66, 2013.
• Web of Science Citations: 18

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in people above age 65. Platelet studies with ADAM10 have shown that its expression is reduced in AD patients. The aim of this research was to compare the platelet levels of ADAM10 protein in two Brazilian elderly groups, considering the stages of the disease. The SDS-PAGE technique followed by Western blotting was used. Data were analyzed using comparison, correlation and association statistical methods. The results showed reduced platelet ADAM10 levels in AD elderly compared to non-AD subjects. The disease progression intensified this reduction. ADAM10 was the only statistically significant variable (p = 0.01) to increase the AD occurrence probability. The cutoff value of 0.4212 in the receiver operating characteristic curve captured sensitivity and specificity of 70 and 80.77%, respectively. Together with other clinical criteria, ADAM10 seems to be a relevant biomarker tool for early and accurate AD diagnosis. Copyright (C) 2013 S. Karger AG, Basel (AU)

• FAPESP's process: 12/22529-0 - ADAM10 as a biomarker for Alzheimer's Disease: a study with Brazilian elderly
• Grantee: Márcia Regina Cominetti
• Support type: Regular Research Grants - Publications - Scientific article
• FAPESP's process: 10/09497-7 - Platelet levels of ADAM10 in tracking Alzheimer's disease: contributions for nursing care
• Grantee: Sofia Cristina Iost Pavarini
• Support type: Regular Research Grants