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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Medial prefrontal cortex N-methyl-D-aspartate receptor/nitric oxide/cyclic guanosine monophosphate pathway modulates both tachycardic and bradycardic baroreflex responses

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Ferreira-Junior, Nilson C. [1] ; Fedoce, Alessandra G. [1] ; Alves, Fernando H. F. [1] ; Resstel, Leonardo B. M. [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Neuroscience Research; v. 91, n. 10, p. 1338-1348, OCT 2013.
Web of Science Citations: 9

Neural reflex mechanisms, such as the baroreflex, are involved in regulating cardiovascular system activity. Previous results showed that the ventral portion of the medial prefrontal cortex (vMPFC) is involved in modulation only of the cardiac baroreflex bradycardic component. Moreover, vMPFC N-methyl-D-aspartate (NMDA) receptors modulate the bradycardia baroreflex, but the baroreflex tachycardic component has not been investigated. Furthermore, glutamatergic neurotransmission into the vMPFC is involved in activation of the cardiac sympathetic and parasympathetic nervous system. Finally, it has been demonstrated that glutamatergic neurotransmission into the vMPFC can be modulated by the endocannabinoid system and that activation of the CB1 cannabinoid receptor by anandamide, an endocannabinoid, can decrease both cardiac baroreflex bradycardic and tachycardic responses. Thus, there is the possibility that glutamatergic neurotransmission into the vMPFC does not modulate only the cardiac bradycardic component of the baroreflex. Therefore, the present study investigated whether glutamatergic neurotransmission into the vMPFC modulates both cardiac baroreflex bradycardic and tachycardic responses. We found that vMPFC bilateral microinjection of the NMDA receptor antagonist AP7 (4 nmol/200 nl), of a selective inhibitor of neuronal nitric oxide (NO) synthase N-propyl (0.08 nmol/200 nl), of the NO scavenger carboxy-PTIO (2 nmol/200 nl), or of the NO-sensitive guanylate cyclase ODQ (2 nmol/200 nl) decreased the baroreflex activity in unanesthetized rats. Therefore, our results demonstrate the participation of NMDA receptors, production of NO, and activation of guanylate cyclase in the vMPFC in the modulation of both cardiac baroreflex bradycardic and tachycardic responses. (c) 2013 Wiley Periodicals, Inc. (AU)

FAPESP's process: 10/09462-9 - Study of peripheral mechanisms involved in the cardiovascular response during sepsis in rats: possible involvement of the endocannabinoid system
Grantee:Fernando Henrique Ferrari Alves
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/20762-7 - Possible involvement of oxidative/nitrosative stress induced by restraint stress in modulation of conditioned emotional response
Grantee:Alessandra das Graças Fedoce
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/07332-3 - Possible role of dorsal hippocampus on behaviour and autonomic responses during defensive responses: involvement of NMDA receptor/nitric oxide and endocanabinoid
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants
FAPESP's process: 11/19494-8 - Involvement of the dorsal hippocampus in the modulation of cardiac baroreflex activity: implication of NMDA, CB1, TRPV1 and muscarinic receptors and of the nitric oxide.
Grantee:Nilson Carlos Ferreira Junior
Support type: Scholarships in Brazil - Doctorate