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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Excess androgen during perinatal life alters steroid receptor expression, apoptosis, and cell proliferation in the uteri of the offspring

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Author(s):
Guerra, Marina T. [1] ; Sanabria, Marciana [2] ; Grossman, Gail [3, 4] ; Petrusz, Peter [3, 4] ; Kempinas, Wilma de Grava [2]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[2] Univ Estadual Paulista, Inst Biosci, Dept Morphol, UNESP, Botucatu, SP - Brazil
[3] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC - USA
[4] Univ N Carolina, Labs Reprod Biol, Chapel Hill, NC - USA
Total Affiliations: 4
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 40, p. 1-7, SEP 2013.
Web of Science Citations: 7
Abstract

Exposure to environmental chemicals may contribute to reproductive disorders, especially when it occurs in critical periods of development. The female reproductive system can be a target for androgens derived from environmental contaminants or pathological conditions. The purpose of this study was to assess the long-term effects of androgens on uterine tissue after maternal exposure limited to the time of gestation and lactation. Pregnant Wistar rats were treated with testosterone propionate (TP) at 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg or corn oil (vehicle), s.c., from gestational day 12 until the end of lactation. The results show changes in the pattern of expression of receptors for estrogen, progesterone, and androgen at all doses tested, and decreases in both apoptosis and cell proliferation indices at 0.1 and 0.2 mg/kg. We conclude that early TP exposure, under these experimental conditions, causes changes in cellular and molecular parameters that are essential for normal uterine function in the adult. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/00352-9 - Structure of the genital tract and reproductive function of female rats exposed to testosterone propionate in utero and during lactation
Grantee:Marina Trevizan Guerra
Support type: Scholarships in Brazil - Doctorate