Microbial Biotransformation of 16 alpha,17-Epoxy-ent-kaurane-19-oic acid by Beauveria sulfurescens ATCC 7159-F

Author(s)

Furtado, Ricardo A. ^[1] ; Gunaherath, G. M. Kamal B. ^[1] ; Bastos, Jairo K. ^[2] ; Gunatilaka, A. A. Leslie ^[1]

Affiliation

^[1] Univ Arizona, SW Ctr Nat Prod Res & Commercializat, Sch Nat Resources & Environm, Coll Agr & Life Sci, Tucson, AZ 85706 - USA

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT COMMUNICATIONS; v. 8, n. 8, p. 1041-1044, AUG 2013.
• Web of Science Citations: 5

Abstract

Biotransformation of 16 alpha,17-epoxy-ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7 beta,17-dihydroxy-ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics. (AU)

• FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 09/16081-4 - Phytochemical study of Copaifera langsdorffii aerial parts and the evaluation of its analgesic, anti-inflammatory and immunomodulatory activities
• Grantee: Ricardo Andrade Furtado
• Support Opportunities: Scholarships in Brazil - Doctorate