| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs - England
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 15, n. 10, p. 2434-2437, MAY 17 2013. |
| Web of Science Citations: | 21 |
| Abstract | |
The coupling between cyclic and acyclic a-amino acid derivatives and methyl acrylate, mediated by samarium diiodide, is described. The method constitutes a powerful tool to construct indolizidine, quinolizidine, and piperidine systems in a straightforward two-step fashion. The formal synthesis of (-)-pumiliotoxin 251D and (+/-)-epiquinamide is achieved after two or three steps from these amino acid derivatives. (AU) | |
| FAPESP's process: | 12/04685-5 - New synthetic methodologies for the construction of pyrrolidine, piperidine and indolizidine systems |
| Grantee: | Antonio Carlos Bender Burtoloso |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 08/09653-9 - Total syntheses of the cardiotonics pumiliotoxin 209 F and homopumiliotoxin 223 G |
| Grantee: | Vagner Dantas Pinho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |