| Full text | |
| Author(s): Show less - |
Rasmussen, Lucas
[1, 2]
;
Delabio, Roger
[3]
;
Horiguchi, Lie
[3]
;
Mizumoto, Igor
[3]
;
Terazaki, Carlos-Renato
[3]
;
Mazzotti, Diego
[1]
;
Bertolucci, Paulo-Henrique
[1]
;
Pinhel, Marcela-Augusta
;
Souza, Doroteia
;
Krieger, Henrique
[4]
;
Kawamata, Carlos
[4]
;
Minett, Thais
[5]
;
Smith, Marilia Cardoso
[1]
;
Payao, Spencer-Luiz
[3, 2]
Total Authors: 14
|
| Affiliation: | [1] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil
[2] USC, Sao Paulo - Brazil
[3] Fac Med Marilia FAMEMA, Hemoctr, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo - Brazil
[5] Univ Cambridge, Cambridge - England
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | JOURNAL OF ALZHEIMER'S DISEASE; v. 36, n. 4, p. 733-738, 2013. |
| Web of Science Citations: | 10 |
| Abstract | |
Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) of the interleukin 6 gene (IL-6) promoter region {[}-174G/C (rs 1800795), -572C/G (rs 1800796), and -597G/A (rs 1800797)] in 200 patients with late-onset AD and 165 elderly controls in a Brazilian case-control population sample. Genotyping was carried out from blood cells using PCR-RFLP techniques. Statistical analysis was performed to evaluate the Hardy-Weinberg equilibrium and to compare frequencies between groups. No association was found between any IL-6 polymorphism and AD; however the haplotype composed of the -597 A allele and the -174G allele indicated a crude odds ratio (OR) of 0.15 (p = 0.0021) and a significantly adjusted OR (adjusted for the APOE E4 allele value) of 0.15 (p = 0.00294). Linkage disequilibrium was D' =0.68 among the three SNPs. Our findings revealed a protective effect of AG (-597A, -174G) haplotype, which worked independently of the APOE E4 allele in our Brazilian population sample. Thus, the promoter region of IL-6 gene probably exerts an effect through gene linkage and/or gene interaction. (AU) | |
| FAPESP's process: | 04/15273-3 - Characterization of ribosomal genes and of apolipoprotein AV and interleukin 6, 8 and 1st (alpha) polymorphisms in patients with Alzheimer's Disease |
| Grantee: | Spencer Luiz Marques Payão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/15857-9 - Ribosomal gene expression of B-amyloid precursor protein, of presenilin and cytokines in brain and blood samples of Alzheimer's disease patients by Real Time PCR technique |
| Grantee: | Spencer Luiz Marques Payão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 06/07240-3 - Lipids metabolism-related gene polymorphisms, diseases, laboratory exams in a Brazilian elderly cohort from districtal region of São Paulo |
| Grantee: | Marilia de Arruda Cardoso Smith |
| Support Opportunities: | Regular Research Grants |