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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study

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Author(s):
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Rasmussen, Lucas [1, 2] ; Delabio, Roger [3] ; Horiguchi, Lie [3] ; Mizumoto, Igor [3] ; Terazaki, Carlos-Renato [3] ; Mazzotti, Diego [2] ; Bertolucci, Paulo-Henrique [2] ; Pinhel, Marcela-Augusta ; Souza, Doroteia ; Krieger, Henrique [4] ; Kawamata, Carlos [4] ; Minett, Thais [5] ; Smith, Marilia Cardoso [2] ; Payao, Spencer-Luiz [3, 1]
Total Authors: 14
Affiliation:
[1] USC, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil
[3] Fac Med Marilia FAMEMA, Hemoctr, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo - Brazil
[5] Univ Cambridge, Cambridge - England
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 36, n. 4, p. 733-738, 2013.
Web of Science Citations: 10
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) of the interleukin 6 gene (IL-6) promoter region {[}-174G/C (rs 1800795), -572C/G (rs 1800796), and -597G/A (rs 1800797)] in 200 patients with late-onset AD and 165 elderly controls in a Brazilian case-control population sample. Genotyping was carried out from blood cells using PCR-RFLP techniques. Statistical analysis was performed to evaluate the Hardy-Weinberg equilibrium and to compare frequencies between groups. No association was found between any IL-6 polymorphism and AD; however the haplotype composed of the -597 A allele and the -174G allele indicated a crude odds ratio (OR) of 0.15 (p = 0.0021) and a significantly adjusted OR (adjusted for the APOE E4 allele value) of 0.15 (p = 0.00294). Linkage disequilibrium was D' =0.68 among the three SNPs. Our findings revealed a protective effect of AG (-597A, -174G) haplotype, which worked independently of the APOE E4 allele in our Brazilian population sample. Thus, the promoter region of IL-6 gene probably exerts an effect through gene linkage and/or gene interaction. (AU)

FAPESP's process: 09/15857-9 - Ribosomal gene expression of B-amyloid precursor protein, of presenilin and cytokines in brain and blood samples of Alzheimer's disease patients by Real Time PCR technique
Grantee:Spencer Luiz Marques Payão
Support type: Regular Research Grants
FAPESP's process: 04/15273-3 - Characterization of ribosomal genes and of apolipoprotein AV and interleukin 6, 8 and 1st (alpha) polymorphisms in patients with Alzheimer's Disease
Grantee:Spencer Luiz Marques Payão
Support type: Regular Research Grants
FAPESP's process: 06/07240-3 - Lipids metabolism-related gene polymorphisms, diseases, laboratory exams in a Brazilian elderly cohort from districtal region of São Paulo
Grantee:Marilia de Arruda Cardoso Smith
Support type: Regular Research Grants