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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural products as candidates for useful drugs in the treatment of Alzheimer's disease

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Author(s):
Viegas Junior, Cláudio [1] ; Bolzani, Vanderlan da Silva ; Furlan, Maysa ; Fraga, Carlos Alberto Manssour ; Barreiro, Eliezer J.
Total Authors: 5
Affiliation:
[1] Universidade Estadual Paulista (UNESP). Campus de Araraquara - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Química Nova; v. 27, n. 4, p. 655-660, jul.-ago. 2004.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Abstract

Alzheimer's disease (AD) is progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors. (AU)

FAPESP's process: 03/05512-8 - Planning, synthesis and pharmacological evaluation of new antiinflammatory and acetylcholinesterase inhibiting piperidinil derivatives
Grantee:Claudio Viegas Junior
Support type: Scholarships in Brazil - Post-Doctorate