Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral Infections and Orofacial Pain in Alzheimer's Disease: A Case-Control Study

Full text
Author(s):
Rolim, Thais de Souza [1, 2] ; Campos Fabri, Gisele Maria [3] ; Nitrini, Ricardo [1, 4] ; Anghinah, Renato [5] ; Teixeira, Manoel Jacobsen [1, 6] ; de Siqueira, Jose Tadeu T. [7, 8] ; Ferrari Cestari, Jose Augusto [7] ; de Siqueira, Silvia Regina Dowgan T. [7, 9]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Neurol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Orofacial Team, Hosp Clin, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Hosp Clin, Dent Div, Cent Inst, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Hosp Clin, Cognit Neurol & Behav Grp, BR-05508 Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Hosp Clin, Cognit Neurol & Behav Grp, Neurol Div, BR-05508 Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Hosp Clin, Funct Neurosurg Div, Psychiat Inst, BR-05508 Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Med, Hosp Clin, Grp Oral Med & Neurosci, Dent Div, Psychiat Inst, BR-05508 Sao Paulo - Brazil
[8] Univ Sao Paulo, Sch Med, Hosp Clin, Orofacial Pain Team, Dent Div, BR-05508 Sao Paulo - Brazil
[9] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508 Sao Paulo - Brazil
Total Affiliations: 9
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 38, n. 4, p. 823-829, 2014.
Web of Science Citations: 22
Abstract

Background: Dental infections are frequent and have recently been implicated as a possible risk factor for Alzheimer's disease (AD). Despite a lack of studies investigating orofacial pain in this patient group, dental conditions are known to be a potential cause of pain and to affect quality of life and disease progression. Objectives: To evaluate oral status, mandibular function and orofacial pain in patients with mild AD versus healthy subjects matched for age and gender. Methods: Twenty-nine patients and 30 control subjects were evaluated. The protocol comprised a clinical questionnaire and dental exam, research diagnostic criteria for temporomandibular disorders, the McGill Pain Questionnaire, the decayed, missing, and filled teeth index, and included a full periodontal evaluation. AD signs and symptoms as well as associated factors were evaluated by a trained neurologist. Results: A higher prevalence of orofacial pain (20.7%, p < 0.001), articular abnormalities in temporomandibular joints (p < 0.05), and periodontal infections (p = 0.002) was observed in the study group compared to the control group. Conclusion: Orofacial pain and periodontal infections were more frequent in patients with mild AD than in healthy subjects. Orofacial pain screening and dental and oral exams should be routinely performed in AD patients in order to identify pathological conditions that need treatment thus improving quality of life compromised due to dementia. (AU)

FAPESP's process: 07/04930-1 - Odontogenic infection and its association with Alzheimer's Disease
Grantee:Silvia Regina Dowgan Tesseroli de Siqueira
Support Opportunities: Regular Research Grants
FAPESP's process: 07/06852-8 - Dental infection and its association with Alzheimer's Disease
Grantee:Thaís de Souza Rolim
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/18756-9 - Mild cognitive impairment and Alzheimer's disease: prevalence of oral infection and seric levels of inflammatory parameters
Grantee:Silvia Regina Dowgan Tesseroli de Siqueira
Support Opportunities: Regular Research Grants