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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy, and beyond

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Author(s):
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Vatansever, Fatma [1, 2] ; de Melo, Wanessa C. M. A. [1, 3] ; Avci, Pinar [1, 2, 4] ; Vecchio, Daniela [1, 2] ; Sadasivam, Magesh [1, 5] ; Gupta, Asheesh [1, 2, 6] ; Chandran, Rakkiyappan [1, 5] ; Karimi, Mahdi [1, 7, 8] ; Parizotto, Nivaldo A. [1, 2, 9] ; Yin, Rui [1, 2, 10] ; Tegos, George P. [1, 2, 11, 12] ; Hamblin, Michael R. [1, 2, 13]
Total Authors: 12
Affiliation:
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[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 - USA
[2] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 - USA
[3] Univ Sao Paulo, Sao Carlos, SP - Brazil
[4] Semmelweis Univ, Sch Med, Dept Dermatol, Budapest - Hungary
[5] Amity Univ Uttar Pradesh, Amity Inst Nanotechnol, Noida - India
[6] Def Inst Physiol & Allied Sci, Delhi - India
[7] Tarbiat Modares Univ, Fac Biol Sci, Dept Nanobiotechnol, Tehran - Iran
[8] Tarbiat Modares Univ, Fac Biol Sci, Dept Biophys, Tehran - Iran
[9] Univ Fed Sao Carlos, Dept Physiotherapy, Lab Electromorphophototherapy, BR-13560 Sao Carlos, SP - Brazil
[10] Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing - Peoples R China
[11] Univ New Mexico, Ctr Mol Discovery, Albuquerque, NM 87131 - USA
[12] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 - USA
[13] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 - USA
Total Affiliations: 13
Document type: Review article
Source: FEMS MICROBIOLOGY REVIEWS; v. 37, n. 6, p. 955-989, NOV 2013.
Web of Science Citations: 224
Abstract

Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial activity, which accounts for their versatility in mediating host defense against a broad range of pathogens. Most ROS are formed by the partial reduction in molecular oxygen. Four major ROS are recognized comprising superoxide (O2(center dot-)), hydrogen peroxide (H2O2), hydroxyl radical ((OH)-O-center dot), and singlet oxygen (O-1(2)), but they display very different kinetics and levels of activity. The effects of O2(center dot-) and H2O2 are less acute than those of center dot OH and O-1(2), because the former are much less reactive and can be detoxified by endogenous antioxidants (both enzymatic and nonenzymatic) that are induced by oxidative stress. In contrast, no enzyme can detoxify (OH)-O-center dot or O-1(2), making them extremely toxic and acutely lethal. The present review will highlight the various methods of ROS formation and their mechanism of action. Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered. Antimicrobial approaches primarily utilizing ROS comprise both bactericidal antibiotics and nonpharmacological methods such as photodynamic therapy, titanium dioxide photocatalysis, cold plasma, and medicinal honey. A brief final section covers reactive nitrogen species and related therapeutics, such as acidified nitrite and nitric oxide-releasing nanoparticles. (AU)

FAPESP's process: 12/05919-0 - Effects of low level laser therapy on modulation of the transcriptome, immunohistochemistry of muscle tissue and physical performance of young men undergoing physical strength training
Grantee:Cleber Ferraresi
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/06240-8 - Effects of Biosilicate® associated with low level laser therapy during bone repair in rats
Grantee:Nivaldo Antonio Parizotto
Support type: Regular Research Grants
FAPESP's process: 10/07194-7 - Use of low-level laser and light-emitting diode therapy to increase muscle performance: from in vitro and experimental studies to clinical applications
Grantee:Cleber Ferraresi
Support type: Scholarships in Brazil - Doctorate