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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biochemical biomarkers in Scinax fuscovarius tadpoles exposed to a commercial formulation of the pesticide fipronil

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Stefani Margarido, Tatiana Cristina [1] ; Felicio, Andreia Arantes [1] ; Rossa-Feres, Denise de Cerqueira [2] ; de Almeida, Eduardo Alves [1]
Total Authors: 4
[1] Univ Estadual Paulista, Dept Chem & Environm Sci, Sao Paulo State Univ Sao Jose do Rio Preto, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista, Dept Bot & Zool, Sao Paulo State Univ Sao Jose do Rio Preto, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MARINE ENVIRONMENTAL RESEARCH; v. 91, n. SI, p. 61-67, OCT 2013.
Web of Science Citations: 16

One of the main pesticides used in the cultivation of sugarcane in Sao Paulo State, Brazil, is Regent (R) 800WG, the main active compound of which is fipronil. Fipronil is a potent insecticide that eliminates pests, including insects resistant to pyrethroids, organophosphates (OP) and carbamates (CA). There is little known on the toxic effects of fipronil on non-target organisms, such as tadpoles of frogs. It is possible that this compound carries a high toxicity for these organisms, since the pesticide can be incorporated into aquatic environments during the rainy season, a time which coincides with the time of amphibian reproduction and the occurrence of tadpoles in the aquatic environment in this region. Thus, the pesticide could be contributing to the decline of amphibians in the northwest region of Sao Paulo state due to its wide use. This study aimed to test the influence of Regent (R) 800WG on some biochemical systems of tadpoles (such as antioxidant defense systems) at different stages of development. The results of analysis from in vivo exposures demonstrated that only a few parameters in the groups exposed to fipronil responded to exposure to Regent (R) 800WG, results which indicate that the pesticide instigates biochemical responses in tadpoles. Although catalase and glucose-6-phosphate dehydrogenase (G6PDH) were unchanged during the experiments, glutathione-S-transferase (GST) was inhibited in tadpoles, and the activity of glutathione reductase (GR) varied according to the exposure period and pesticide concentration. This data demonstrated the influence of the fipronil formulation on the metabolism of tadpoles, and showed that it can increase their susceptibility to environmental contaminants. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/58032-7 - Petrodiesel vs. biodiesel: a comparative study on their toxic effects in Nile tilapia and armoured catfishes
Grantee:Eduardo Alves de Almeida
Support type: Program for Research on Bioenergy (BIOEN) - Regular Program Grants
FAPESP's process: 09/12636-1 - Evaluation of biochemical biomarkers in anuran tadpoles exposed to the pesticide RegentGW800
Grantee:Tatiana Cristina Stefani Margarido
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/52321-7 - Diversity and ecology of tadpoles from Central Amazonia
Grantee:Denise de Cerqueira Rossa-Feres
Support type: BIOTA-FAPESP Program - Regular Research Grants