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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of Cardiac Involvement During Dengue Viral Infection

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Miranda, Carlos Henrique [1] ; Borges, Marcos de Carvalho [1] ; Matsuno, Alessandra Kimie [2] ; Vilar, Fernando Crivelenti [1] ; Gali, Luis Gustavo [1] ; Volpe, Gustavo Jardim [1] ; Schmidt, Andre [1] ; Pazin-Filho, Antonio [1] ; Figueira da Silva, Fernanda Miquelitto [1] ; de Castro-Jorge, Luiza Antunes [1] ; de Oliveira, Mayra Fernanda [1] ; Saggioro, Fabiano [3] ; Martines, Roosecelis Brasil [4] ; Lopes da Fonseca, Benedito Antonio [1]
Total Authors: 14
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Internal Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pathol, Sao Paulo - Brazil
[4] Adolfo Lutz Inst, Pathol Ctr, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinical Infectious Diseases; v. 57, n. 6, p. 812-819, SEP 15 2013.
Web of Science Citations: 34

Background. Dengue is a disease whose clinical manifestations range from asymptomatic infections to a severe disease. There have been some previous reports of myocardial involvement in dengue, but this association has not been completely established. Methods. From January to July of 2011, patients hospitalized with dengue, confirmed through dengue nonstructural protein 1 and/or immunoglobulin M detection, were included in this study and troponin I and N terminal fragment of B-type natriuretic peptide levels were determined. Patients with abnormal biomarkers underwent echocardiography and when any abnormality was detected, they underwent cardiac magnetic resonance imaging. Results. Eighty-one patients were evaluated and 12 patients (15%) presented with elevated biomarker levels. Compared to controls, they had higher leukocyte (P < .001) and platelet counts (P = .005); higher C-reactive protein (P = .02), and a lower viral load (P = .03). There was no difference according to clinical dengue classification; dengue hemorrhagic fever/dengue shock syndrome severity; duration of symptoms; or prevalence of secondary infection between the 2 groups. Two patients died secondary to cardiogenic shock before imaging studies. Necroscopic findings were compatible to myocarditis in both, and immunohistochemistry for dengue virus showed increased staining on mononuclear cells located in the myocardial tissue. Of the 10 patients who underwent echocardiography, depressed left ventricular ejection fraction (LVEF) was identified in 1, left ventricular segmental abnormalities with preserved LVEF in 2, and an important pericardial effusion with tamponade in another. Cardiac involvement was confirmed by CMR in these 4 patients. Conclusions. Dengue viruses were shown to cause cardiac disease with clinical manifestations ranging from mild elevation of biomarkers to myocarditis and/or pericarditis. (AU)

FAPESP's process: 09/14449-4 - Evaluation of the prevalence of dengue infection in Ribeirão Preto, São Paulo State, and the evaluation of the detection of NS1 protein of dengue viruses during the inter-epidemic period in sera from patients suspect of having dengue
Grantee:Benedito Antônio Lopes da Fonseca
Support type: Regular Research Grants
FAPESP's process: 11/22514-0 - Study of the viral, genetic and immunologic characteristics of human host on the development of asymptomatic and severe clinical manifestations of dengue
Grantee:Benedito Antônio Lopes da Fonseca
Support type: Regular Research Grants