(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)
alpha,beta-Unsaturated Diazoketones as Versatile Building Blocks for the Synthesis of Hydroxylated Piperidines, Indolizidines and Quinolizidines
Lordello, Leonardo D.
Burtoloso, Antonio C. B.
Total Authors: 3
 Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
CURRENT TOPICS IN MEDICINAL CHEMISTRY;
Web of Science Citations:
A four-step approach for the synthesis of dihydroxylated piperidine, quinolizidine and indolizidine systems is described employing alpha,beta-unsaturated diazoketones as versatile building blocks. Unsaturated diazoketones were readily prepared from a Horner-Wadsworth-Emmons reaction between a diazophosphonate and amino-aldehydes. The strategy employs an asymmetric dihydroxylation reaction as the key step and is simple and straightforward enough to be extended to other nitrogen heterocycles. (AU)