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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits

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Author(s):
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Ota, Vanessa K. [1, 2] ; Berberian, Arthur A. [1, 3] ; Gadelha, Ary [1, 3] ; Santoro, Marcos L. [2, 1] ; Ottoni, Gustavo L. [4] ; Matsuzaka, Camila T. [3] ; Mari, Jair J. [3] ; Melaragno, Maria I. [2] ; Lara, Diogo R. [4] ; Smith, Marilia A. C. [2] ; Belangero, Sintia I. [1, 3, 2] ; Bressan, Rodrigo A. [1, 3]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, LiNC, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, BR-04023900 Sao Paulo - Brazil
[4] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Porto Alegre, RS - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 209, n. 1, p. 110-113, AUG 30 2013.
Web of Science Citations: 7
Abstract

We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants