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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance

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Damaso, Ana Raimunda [1, 2] ; de Piano, Aline [1] ; da Silveira Campos, Raquel Munhoz [1] ; Corgosinho, Flavia Campos [1] ; Siegfried, Wolfgang [3] ; Caranti, Danielle Arisa [2] ; Landi Masquio, Deborah Cristina [1] ; Carnier, June [1] ; Sanches, Priscila de Lima [1] ; da Silva, Patricia Leao [1] ; Oller Nascimento, Claudia Maria [4] ; Oyama, Lila Missae [4] ; Aguilera Dantas, Alexandre Damaso [5] ; de Mello, Marco Tulio [6] ; Tufik, Sergio [6] ; Tock, Lian [5]
Total Authors: 16
[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Postgrad Program Nutr, BR-04020060 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Biosci, BR-11015020 Santos, SP - Brazil
[3] Obes Rehabil Ctr INSULA, Insulaweg, Bischofswiesen - Germany
[4] Univ Fed Sao Paulo UNIFESP, Dept Physiol, BR-04021001 Sao Paulo - Brazil
[5] Weight Sci, BR-05406000 Sao Paulo - Brazil
[6] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, BR-04021001 Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Web of Science Citations: 24

The prevention of obesity and health concerns related to body fat is a major challenge worldwide. The aim of this study was to investigate the role of a medically supervised, multidisciplinary approach, on reduction in the prevalence of obesity related comorbidities, inflammatory profile, and neuroendocrine regulation of energy balance in a sample of obese adolescents. A total of 97 postpuberty obese adolescents were enrolled in this study. Body composition, neuropeptides, and adipokines were analysed. The metabolic syndrome was defined by the International Diabetes Federation (IDF). The abdominal ultrasonography was performed to measure visceral, subcutaneous fat and hepatic steatosis. All measures were performed at baseline and after one year of therapy. The multidisciplinary management promoted the control of obesity reducing body fat mass. The prevalence of metabolic syndrome, asthma, nonalcoholic fatty liver disease (NAFLD), binge eating, and hyperleptinemia was reduced. An improvement in the inflammatory profile was demonstrated by an increase in anti-inflammatory adiponectin and reduction in proinflammatory adipokines, plasminogen activator inhibitor-1, interleukin-6 concentrations, and in the Lep/Adipo ratio. Moreover, a reduction in the AgRP and an increase in the alfa-MSH were noted. The multidisciplinary approach not only reduced obesity but also is efficacious in cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants