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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice

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de Oliveira, Krishna Duro [1] ; Tedardi, Marcello Vannucci [1] ; Cogliati, Bruno [1] ; Zaidan Dagli, Maria Lucia [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 11

Gap junctions are communicating junctions which are important for tissue homeostasis, and their disruption is involved in carcinogenic processes. This study aimed to verify the influence of deletion of one allele of the Connexin 43 gene on cancer incidence in different organs. The 7,12-dimethylbenzanthracene (DMBA) carcinogenic model, using hebdomadary doses by gavage of 9 mg per animal, was used to induce tumors in Connexin 43 heterozygous or wild-type mice. The experiment began in the eighth week of the mice life, and all of them were euthanized when reaching inadequate physical condition, or at the end of 53 weeks. No statistical differences occurred for weight gain and cancer survival time (P = 0.9853) between heterozygous and wild-type mice. Cx43(+/-) mice presented significantly higher susceptibility to lung cancer (P = 0.0200) which was not evidenced for benign neoplasms (P = 0.3449). In addition, incidence of ovarian neoplasms was 2.5-fold higher in Cx43(+/-) mice, although not statistically significant. Other organs showed a very similar cancer occurrence between Cx43 groups. The experiment strengthens the evidence of the relationship between Connexin 43 deficiency and carcinogenesis. (AU)

FAPESP's process: 10/08480-3 - Mammary carcinogenesis induced by DMBA in genetically modified mice, deficient in Cx43
Grantee:Maria Lucia Zaidan Dagli
Support type: Regular Research Grants
FAPESP's process: 10/00874-2 - Evaluation of the expression of receptors for estrogen, progesteron, E-cadherin, cytokeratins 5 and 14, vimentin, c-kit, PCNA and PTEN in mammary neoplasms induced by DMBA in BALB/c mice
Grantee:Marcello Vannucci Tedardi
Support type: Scholarships in Brazil - Scientific Initiation