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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Iontophoresis on Topical Delivery of Doxorubicin-Loaded Solid Lipid Nanoparticles

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Author(s):
Taveira, Stephania F. [1] ; De Santana, Danielle C. A. S. [2] ; Araujo, Luciana M. P. C. [2] ; Marquele-Oliveira, Franciane [2] ; Nomizo, Auro [2] ; Lopez, Renata F. V. [2]
Total Authors: 6
Affiliation:
[1] Univ Fed Goias, Sch Pharm, BR-74605010 Goiania, Go - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY; v. 10, n. 7, p. 1382-1390, JUL 2014.
Web of Science Citations: 27
Abstract

The combination of iontophoresis with solid lipid nanoparticles (SLNs) for targeting drug delivery to the epidermis has not been explored. The goal of this paper was to study the influence of iontophoresis on the penetration of doxorubicin (DOX) delivered in SLNs (DOX-SLNs). We measured the contribution of electroosmotic flow to the transport of DOX, and the accumulation of DOX in the stratum corneum (SC) and in the viable epidermis was determined. In addition, we evaluated the cytotoxicity of DOX-SLNs against skin cancer cells. Iontophoresis of unloaded SLNs decreased the electroosmotic flow by a factor of 5 and increased the skin resistance. Nevertheless, iontophoresis of DOX-SLNs increased DOX delivery to the viable epidermis, with 56% of all DOX penetrating this skin layer. Only 26% of the drug was retained in the SC. In contrast, passive delivery retained 43% of DOX in the SC and 26% in the viable epidermis. DOX-SLNs increased DOX cytotoxicity against melanoma cells by 50%. These results suggest the use of DOX-SLN iontophoresis in the topical treatment of skin cancer. (AU)

FAPESP's process: 11/06202-9 - Influence of low frequency sonophoresis on skin penetration of nanoparticles aiming the skin cancer treatment
Grantee:Renata Fonseca Vianna Lopez
Support type: Regular Research Grants