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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serum levels of inflammatory markers in type 2 diabetes patients with chronic periodontitis

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Author(s):
Longo, Priscila Larcher [1] ; Carillo Artese, Hilana Paula [2] ; Rabelo, Mariana de Sousa [2] ; Kawamoto, Dione [1] ; Foz, Adriana Moura [2] ; Romito, Giuseppe Alexandre [2] ; Dib, Sergio Atala [3] ; Alves Mayer, Marcia Pinto [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Periodont, BR-05508900 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Sch Med, Dept Endocrinol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Applied Oral Science; v. 22, n. 2, p. 103-108, MAR-APR 2014.
Web of Science Citations: 17
Abstract

Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear. Objective: This study aimed to evaluate serum levels of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis. Material and Methods: Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions: Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups. (AU)

FAPESP's process: 11/18618-5 - Subgingival microbiota diversity and serum and gingival fluid cytokines profile related to glycemic control in subjects with Type II Diabetes
Grantee:Marcia Pinto Alves Mayer
Support Opportunities: Regular Research Grants