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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationships between sleep and addiction: The role of drug-environment conditioning

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Author(s):
Berro, Lais F. [1] ; Frussa-Filho, Roberto [1, 2] ; Tufik, Sergio [1] ; Andersen, Monica L. [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04021002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pharmacol, BR-04021002 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Medical Hypotheses; v. 82, n. 3, p. 374-376, MAR 2014.
Web of Science Citations: 4
Abstract

Addiction to cocaine and other amphetamine-like psychostimulants is a chronic relapsing disorder characterized by loss of control over drug taking. Sleep disturbance is common among patients in recovery from drug abuse and can precipitate relapse. It has been widely demonstrated that sleep deprivation and psychostimulants share similar neurobiological effects regarding the dopaminergic system. In addition, the persistence of a drug-environment conditioning induced by repeated psychostimulant treatment, which is deeply related to the dopaminergic neurotransmission, is thought to play a key role in the addictive cycle. In this scenario, we hypothesized that sleep deprivation is a potential detrimental factor to the extinction process of previously established drug-environment conditioning. Therefore, sleep deprivation would extend the pairing between the cocaine reinforcing effects and the environmental cues, thereby leading drug abusers to relapse. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/16580-0 - Effects of different stressors on addiction extinction and reinstatement in animal models
Grantee:Laís Fernanda Berro
Support type: Scholarships in Brazil - Master