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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

What is the best treatment to decrease pro-inflammatory cytokine release in acute skeletal muscle injury induced by trauma in rats: low-level laser therapy, diclofenac, or cryotherapy?

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de Almeida, Patricia [1] ; Tomazoni, Shaiane Silva [2] ; Frigo, Lucio [3] ; Camillo de Carvalho, Paulo de Tarso [1, 4] ; Vanin, Adriane Aver [1] ; Santos, Larissa Aline [1] ; Albuquerque-Pontes, Gianna Moes [4] ; De Marchi, Thiago [5] ; Tairova, Olga [5] ; Marcos, Rodrigo Labat [4] ; Brandao Lopes-Martins, Rodrigo Alvaro [4, 2] ; Pinto Leal-Junior, Ernesto Cesar [1, 4]
Total Authors: 12
[1] Univ Nove Julho UNINOVE, Postgrad Program Rehabil Sci, BR-01504001 Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Pharmacol & Expt Therapeut, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil
[3] Univ Cruzeiro Sul, Biol Sci & Hlth Ctr, Sao Paulo - Brazil
[4] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, BR-01504001 Sao Paulo - Brazil
[5] Univ Caxias Sul UCS, Sports Med Inst, Caxias do Sul, RS - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Lasers in Medical Science; v. 29, n. 2, SI, p. 653-658, MAR 2014.
Web of Science Citations: 30

Currently, treatment of muscle injuries represents a challenge in clinical practice. In acute phase, the most employed therapies are cryotherapy and nonsteroidal anti-inflammatory drugs. In the last years, low-level laser therapy (LLLT) has becoming a promising therapeutic agent; however, its effects are not fully known. The aim of this study was to analyze the effects of sodium diclofenac (topical application), cryotherapy, and LLLT on pro-inflammatory cytokine levels after a controlled model of muscle injury. For such, we performed a single trauma in tibialis anterior muscle of rats. After 1 h, animals were treated with sodium diclofenac (11.6 mg/g of solution), cryotherapy (20 min), or LLLT (904 nm; superpulsed; 700 Hz; 60 mW mean output power; 1.67 W/cm(2); 1, 3, 6 or 9 J; 17, 50, 100 or 150 s). Assessment of interleukin-1 beta and interleukin-6 (IL-1 beta and IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels was performed at 6 h after trauma employing enzyme-linked immunosorbent assay method. LLLT with 1 J dose significantly decreased (p < 0.05) IL-1 beta, IL-6, and TNF-alpha levels compared to non-treated injured group as well as diclofenac and cryotherapy groups. On the other hand, treatment with diclofenac and cryotherapy does not decrease pro-inflammatory cytokine levels compared to the non-treated injured group. Therefore, we can conclude that 904 nm LLLT with 1 J dose has better effects than topical application of diclofenac or cryotherapy in acute inflammatory phase after muscle trauma. (AU)

FAPESP's process: 10/52404-0 - Low-level laser therapy in skeletal muscle fatigue and post-exercise recovery: Optimal parameters and effects in long-duration exercise
Grantee:Ernesto Cesar Pinto Leal Junior
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/06832-5 - Low-level laser therapy and topical sodium diclofenac in contusion-induced skeletal muscle injury in rats
Grantee:Lúcio Frigo
Support type: Regular Research Grants