| Full text | |
| Author(s): |
Moraes-Neto, T. B.
[1, 2]
;
Scopinho, A. A.
[1]
;
Biojone, C.
[1, 2]
;
Correa, F. M. A.
[1]
;
Resstel, L. B. M.
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 258, p. 364-373, JAN 31 2014. |
| Web of Science Citations: | 16 |
| Abstract | |
The dorsal hippocampus (DH) is a structure of the limbic system that is involved in emotional, learning and memory processes. There is evidence indicating that the DH modulates cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint stress (RS) is an unavoidable stress situation that evokes marked and sustained autonomic changes, which are characterized by elevated blood pressure (BP), intense heart rate (HR) increase and a decrease in cutaneous temperature. In the present study, we investigated the involvement of an N-methyl-D-aspartate (NMDA) glutamate receptor/nitric oxide (NO) pathway of the DH in the modulation of autonomic (arterial BP, HR and tail skin temperature) responses evoked by RS in rats. Bilateral microinjection of the NMDA receptor antagonist AP-7 (10 nmol/500 nL) into the DH attenuated RS-evoked autonomic responses. Moreover, RS evoked an increase in the content of NO2/NO3 in the DH, which are products of the spontaneous oxidation of NO under physiological conditions that can provide an indirect measurement of NO production. Bilateral microinjection of N-propyl-L-arginine (0.1 nmol/500 nL; N-propyl, a neuronal NO synthase (nNOS) inhibitor) or carboxy-PTIO (2 nmol/500 nL; c-PTIO, an NO scavenger) into the DH also attenuated autonomic responses evoked by RS. Therefore, our findings suggest that a glutamatergic system present in the DH is involved in the autonomic modulation during RS, acting via NMDA receptors and nNOS activation. Furthermore, the present results suggest that NMDA receptor/nNO activation has a facilitatory influence on RS-evoked autonomic responses. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders |
| Grantee: | Francisco Silveira Guimaraes |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/07332-3 - Possible role of dorsal hippocampus on behaviour and autonomic responses during defensive responses: involvement of NMDA receptor/nitric oxide and endocanabinoid |
| Grantee: | Leonardo Resstel Barbosa Moraes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/09300-4 - Bed nucleus of the stria terminalis noradrenergic system modulates contextual fear conditionig: possible interaction with CRF and glutamatergic and nitrergic neurotransmission |
| Grantee: | Leonardo Resstel Barbosa Moraes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/00390-0 - Study of envolviment of endocanabinoid system in the medial pre-frontal cortex of rats on the modulation of autonomic responses during restraint stress: possibile interection with glutamatergic and nitrergic systems |
| Grantee: | Teophanes Barbosa Moraes Neto |
| Support Opportunities: | Scholarships in Brazil - Doctorate |