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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

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Author(s):
Kronenberger, Thales [1] ; Lindner, Jasmin [1] ; Meissner, Kamila A. [1] ; Zimbres, Flavia M. [1] ; Coronado, Monika A. [2] ; Sauer, Frank M. [1] ; Schettert, Isolmar [3] ; Wrenger, Carsten [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo - Brazil
[2] Sao Paulo State Univ, Dept Phys, Multi User Ctr Biomol Innovat, UNESP IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: BIOMED RESEARCH INTERNATIONAL; 2014.
Web of Science Citations: 9
Abstract

Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism). (AU)

FAPESP's process: 09/54325-2 - Elucidation of vitamin B metabolism in the human malaria parasite Plasmodium falciparum and their validation as a target for chemotherapy
Grantee:Carsten Wrenger
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/19703-6 - Identification and interference with nutrient transporters integrated to erythrocyte surface by the Human Malaria parasite: Plasmodium falciparum
Grantee:Flávia Menezes Zimbres
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/12807-3 - Analysis of the redox status and its effect on the proliferation of Plasmodium falciparum in genetically different erythrocytes
Grantee:Kamila Anna Meissner
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/13706-3 - Implications from pyridoxine kinase of Plasmodium falciparum and study if its spacer regions
Grantee:Thales Kronenberger
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/20647-0 - Elucidation of vitamin B metabolism in the human malaria parasite plasmodium falciparum and their validation as a target for chemotherapy
Grantee:Carsten Wrenger
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 12/12790-3 - Analysis of the haemoglobin catabolism of Plasmodium falciparum proliferation in genetically modified erythrocytes
Grantee:Jasmin Lindner
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/10288-1 - Analysis of the organelle biogenesis in Plasmodium falciparum by live cell imaging
Grantee:Carsten Wrenger
Support type: Regular Research Grants