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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Seasonal Variation of the Chemical Composition of Essential Oils from Porcelia macrocarpa RE Fries (Annonaceae) and Their Antimicrobial Activity

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Author(s):
da Silva, Erica Biolcati P. [1] ; Soares, Marisi G. [2] ; Mariane, Bruna [1] ; Vallim, Marcelo A. [1] ; Pascon, Renata C. [1] ; Sartorelli, Patricia [1] ; Lago, Joao Henrique G. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
[2] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Molecules; v. 18, n. 11, p. 13574-13587, NOV 2013.
Web of Science Citations: 3
Abstract

This study investigates the impact of seasonal variation on the chemical composition of essential oils from the leaves of Porcelia macrocarpa (Annonaceae) obtained over the course of one year (January-December 2011) and the chemical composition of the essential oils obtained from the ripe fruits of the same plant. Furthermore, the essential oils of the leaves were investigated with respect to their antimicrobial activity. The essential oils of the leaves contain a mixture of monoterpenes, one diterpene and several sesquiterpenes. The main components were identified as the sesquiterpenes germacrene D (29%-50%) and bicyclogermacrene (24%-37%). No significant variation was observed for the composition of the essential oil of the leaves over the course of the year, except for the month of November, when the ripe fruit were collected. In this month, substantially decreased concentrations of germacrene D (28.8 +/- 0.8%) and bicyclogermacrene (23.9 +/- 0.6%) were measured and the emergence of spathulenol (10.4 +/- 0.2%) was observed. The essential oils extracted from the ripe fruit revealed the presence of a variety of monoterpenes, sesquiterpenes and hydrocarbons. The main constituents of these oils were neryl (8.8 +/- 0.2%) and geranyl (27.3 +/- 0.7%) formates, gamma-muurolene (10.3 +/- 0.9%) and dendrolasin (8.23 +/- 0.06%). The antimicrobial activity of the essential oil obtained from the leaves of P. macrocarpa towards a range of bacterial and yeast strains was examined. In order to determine the minimum inhibitory concentration (MIC) of essential oils obtained from the January collection of the leaves, broth microdilution assays were carried out, which showed a significant antimicrobial activity towards Cryptococcus neoformans serotypes A and D as well as C. gattii serotypes B and C. (AU)

FAPESP's process: 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants