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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats

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Author(s):
Melo, Stephano F. S. [1] ; Fernandes, Tiago [1] ; Barauna, Valerio G. [2] ; Matos, Katt C. [1] ; Santos, Alexandra A. S. [3] ; Tucci, Paulo J. F. [3] ; Oliveira, Edilamar M. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Human Movement Biodynam, Lab Biochem & Mol Biol Exercise, Sao Paulo - Brazil
[2] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria - Brazil
[3] Univ Fed Sao Paulo, Sch Med, Dept Physiol, Lab Cardiac Physiol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 33, n. 3, p. 657-669, 2014.
Web of Science Citations: 44
Abstract

Background: Myocardial infarction (MI) is accompanied by cardiac growth, increased collagen deposition, cell death and new vascularization of the cardiac tissue, which results in reduced ventricular compliance. The MiRNA-29 family (29a, 29b, and 29c) targets mRNAs that encode collagens and other proteins involved in fibrosis. In this study we assessed the effects of swimming training (ST) on expression of the cardiac miRNA-29 family and on genes encoding collagen after MI in rats. Methods: ST consisted of 60 min/day/10 weeks and began four weeks after MI. MiRNA and collagen expression analysis were performed in the infarcted region (IR), border region (BR) of the infarcted region and in the remote myocardium (RM) of the left ventricle. Results: MiRNA-29a expression increased 32% in BR and 52% in RM in the TR-INF compared with SED-INF. MiRNA-29c increased by 63% in BR and 55% in RM in TR-INF compared with SED-INF group. COL IAI and COL IIIAI decreased by 63% and 62% in TR-INF, respectively, compared with SED-INF. COLIIIAI expression decreased by 16% in TR-INF compared with SED-INF. Conclusion: Altogether, our results showed that ST restores cardiac miRNA-29 (a and c) levels and prevents COL IAI and COL IIIAI expression in BR and RM, which may contribute to the improvement in ventricular function induced by swimming training, after MI. Copyright (C) 2014 S. Karger AG, Basel (AU)

FAPESP's process: 09/18370-3 - MicroRNA expression on normotensive rats heart submitted to different aerobic training and the potential to hypertension therapy
Grantee:Edilamar Menezes de Oliveira
Support type: Regular Research Grants
FAPESP's process: 10/09438-0 - Therapeutic use of microRNA responsible for regulating cardiac contractility associated with exercise training aerobic in rats with heart failure
Grantee:Stéphano Freitas Soares Melo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants