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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

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Moreno, Mayara Franzoi [1] ; de Morais Honorato de Souza, Gabriel Inacio [1] ; Losinskas Hachul, Ana Claudia [1] ; dos Santos, Bruno [1] ; Okuda, Marcos Hiromu [1] ; Pinto Neto, Nelson Inacio [1] ; Boldarine, Valter Tadeu [1] ; Esposito, Elisa [2] ; Ribeiro, Eliane Beraldi [1] ; da Penha Oller do Nascimento, Claudia Maria [1] ; Ganen, Aline de Piano [1] ; Oyama, Lila Missae [1]
Total Authors: 12
[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Inst Ciencias & Tecnol, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRITION & METABOLISM; v. 11, MAR 28 2014.
Web of Science Citations: 3

Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks {[}groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-kappa B p50. In HC we observed a positive correlation between IL-10 and TNF-alpha in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. (AU)

FAPESP's process: 11/04310-9 - Investigation of a new functional food, coacervate the basis of whey protein and chitosan on the inflammatory response in obese mice induced high fat diet
Grantee:Mayara Franzoi Moreno
Support type: Scholarships in Brazil - Master