Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

Author(s):Show less -

Moreno, Mayara Franzoi ^[1] ; de Morais Honorato de Souza, Gabriel Inacio ^[1] ; Losinskas Hachul, Ana Claudia ^[1] ; dos Santos, Bruno ^[1] ; Okuda, Marcos Hiromu ^[1] ; Pinto Neto, Nelson Inacio ^[1] ; Boldarine, Valter Tadeu ^[1] ; Esposito, Elisa ^[2] ; Ribeiro, Eliane Beraldi ^[1] ; da Penha Oller do Nascimento, Claudia Maria ^[1] ; Ganen, Aline de Piano ^[1] ; Oyama, Lila Missae ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Inst Ciencias & Tecnol, Sao Jose Dos Campos, SP - Brazil

• Document type: Journal article
• Source: NUTRITION & METABOLISM; v. 11, MAR 28 2014.
• Web of Science Citations: 3

Abstract

Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks {[}groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-kappa B p50. In HC we observed a positive correlation between IL-10 and TNF-alpha in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. (AU)

• FAPESP's process: 11/04310-9 - Investigation of a new functional food, coacervate the basis of whey protein and chitosan on the inflammatory response in obese mice induced high fat diet
• Grantee: Mayara Franzoi Moreno
• Support Opportunities: Scholarships in Brazil - Master