| Full text | |
| Author(s): |
Zanoni, Thalita B.
[1]
;
de Paula, Eloisa Silva
[1]
;
Zocolo, Guilherme Juliao
[2]
;
Zanoni, Maria Valnice B.
[2]
;
de Oliveira, Danielle Palma
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Dept Environm Toxicol, Sch Pharmaceut Sci, BR-14049 Ribeirao Preto - Brazil
[2] UNESP, Dept Analyt Chem, Inst Chem Araraquara, Araraquara - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY; v. 95, n. 9, p. 1506-1517, OCT 1 2013. |
| Web of Science Citations: | 0 |
| Abstract | |
Incubation of guanosine and Sudan III induces the formation of a stable adduct, which may be identified using a spectrophotometric technique and mass spectroscopy. The high nucleophilicity of the C-8 position and its proximity to N-7 makes the site susceptible to a nucleophilic attack, which explains the S(N)2 reaction detected between guanosine and Sudan III dye. In addition, direct interaction of Sudan III with calf thymus DNA was monitored using a simple spectrophotometric technique. The results presented indicate that a simple modification of the chemical structure of Sudan I (monoazo dye) to Sudan III (diazo dye) markedly alters reactivity towards nitrogenous DNA bases. (AU) | |
| FAPESP's process: | 08/10449-7 - Assessment of occurrence, toxicity/genotoxicity and degradation processes of dyes in effluents and surface water |
| Grantee: | Maria Valnice Boldrin |
| Support Opportunities: | Research Projects - Thematic Grants |