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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An Historical Perspective on How Advances in Microscopic Imaging Contributed to Understanding the Leishmania Spp. and Trypanosoma cruzi Host-Parasite Relationship

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Florentino, P. T. V. [1] ; Real, F. [1] ; Bonfim-Melo, A. [1] ; Orikaza, C. M. [1] ; Ferreira, E. R. [1] ; Pessoa, C. C. [1] ; Lima, B. R. [1] ; Sasso, G. R. S. [1] ; Mortara, R. A. [1]
Total Authors: 9
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 3

The literature has identified complex aspects of intracellular host-parasite relationships, which require systematic, nonreductionist approaches and spatial/temporal information. Increasing and integrating temporal and spatial dimensions in host cell imaging have contributed to elucidating several conceptual gaps in the biology of intracellular parasites. To access and investigate complex and emergent dynamic events, it is mandatory to follow them in the context of living cells and organs, constructing scientific images with integrated high quality spatiotemporal data. This review discusses examples of how advances in microscopy have challenged established conceptual models of the intracellular life cycles of Leishmania spp. and Trypanosoma cruzi protozoan parasites. (AU)

FAPESP's process: 14/21338-2 - In situ evaluation of acute and chronic infection with Trypanosoma cruzi trypomastigotes (TCI and TcVI) in BALB/c and C57BL/6 inbred mice
Grantee:Bianca Rodrigues Lima Ferreira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/19335-4 - Experimental study on the mechanisms of fusion between heterotypic Leishmania spp. parasitophorous vacuoles
Grantee:Fernando Roberto Oliveira Real
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/05385-8 - Chimeric vacuoles formation with Leishmania amazonensis and Trypanosoma cruzi and participation of d2 subunit of vacuolar ATPase in the biogenesis of Leishmania amazonensis parasitophorous vacuoles
Grantee:Carina Carraro Pessoa
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/23150-5 - Structural and functional characterization of the glycoprotein Ssp-4 of amastigotes forms from Trypanosoma cruzi
Grantee:Pilar Sampaio Tavares Veras
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)