Digestion in Arachnida and the control of proteolytic activity
| Full text | |
| Author(s): |
Morais, Katia L. P.
[1]
;
Mesquita Pasqualoto, Kerly Fernanda
[1]
;
Fernandes Pacheco, Mario Thiego
[1]
;
Berra, Carolina Maria
[1]
;
Alvarez-Flores, Miryam Paola
[1]
;
Chudzinski-Tavassi, Ana Marisa
[1]
Total Authors: 6
|
| Affiliation: | [1] Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | Toxin Reviews; v. 33, n. 1-2, SI, p. 48-52, MAR-JUN 2014. |
| Web of Science Citations: | 3 |
| Abstract | |
Hematophagous organisms have been described to possess specific blood coagulation inhibitors with different structures and novel mechanism of action. A factor Xa inhibitor was identified through the salivary glands transcriptome from the adult Amblyomma cajennense tick. The recombinant form was expressed in Escherichia coli and named Amblyomin-X. The recombinant protein not only inhibits factor X, but is also able to inhibit the activation of factor X by the extrinsic tenase complex. It seems to activate the apoptosis pathway through proteasome inhibition and endoplasmic reticulum-stress. It promotes regression and reduction of lung metastasis in murine melanoma tumor, and does not affect normal cells, emphasizing its selectivity of action. (AU) | |
| FAPESP's process: | 11/05969-4 - Investigating the role of dynein in the mechanism of antitumor action of Amblyomin-X in melanoma cells and pancreatic adenocarcinoma |
| Grantee: | Mario Thiego Fernandes Pacheco |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 10/07958-7 - Evaluation of the pro-apoptotic mechanism of action of the Amblyomin-X |
| Grantee: | Kátia Luciano Pereira Morais |
| Support type: | Scholarships in Brazil - Doctorate |