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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Snake venom L-amino acid oxidases: an overview on their antitumor effects

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Author(s):
Costa, Tassia R. [1] ; Burin, Sandra M. [1] ; Menaldo, Danilo L. [1] ; de Castro, Fabiola A. [1] ; Sampaio, Suely V. [2, 1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin Toxicol & Bromatol Anal, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 20, JUN 2 2014.
Web of Science Citations: 38
Abstract

The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/ or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins. (AU)

FAPESP's process: 11/02645-3 - Functional characterization and mechanisms responses from damage caused by L-aminoacid oxidase from Calloselasma rhodostoma in human cell lines
Grantee:Tássia Rafaella Costa
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis
Grantee:Suely Vilela
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/11963-1 - Effects of a metalloprotease and an acidic Phospholipase A2 from Bothrops atrox snake venom on the complement system and the inflammatory process
Grantee:Danilo Luccas Menaldo
Support type: Scholarships in Brazil - Post-Doctorate