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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuropsychiatric Symptoms in Alzheimer's Disease Are Related to Functional Connectivity Alterations in the Salience Network

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Balthazar, Marcio L. F. [1] ; Pereira, Fabricio R. S. [1] ; Lopes, Tatila M. [1] ; da Silva, Elvis L. [1] ; Coan, Ana Carolina [1] ; Campos, Brunno M. [1] ; Duncan, Niall W. [2] ; Stella, Florindo [3] ; Northoff, Georg [2] ; Damasceno, Benito P. [1] ; Cendes, Fernando [1]
Total Authors: 11
[1] Univ Campinas UNICAMP, Neuroimaging Lab, Dept Neurol, Sch Med Sci, BR-13083970 Campinas, SP - Brazil
[2] Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON - Canada
[3] Sao Paulo State Univ UNESP, Biosci Inst, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Human Brain Mapping; v. 35, n. 4, p. 1237-1246, APR 2014.
Web of Science Citations: 69

Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or resting-state analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy. Hum Brain Mapp 35:1237-1246, 2014. (c) 2013 Wiley Periodicals, Inc. (AU)

FAPESP's process: 09/02179-2 - Study of the cerebral organization of lexical-semantic memory in Alzheimer's Disease, in normal aging and in healthy young adults using functional MRI
Grantee:Marcio Luiz Figueredo Balthazar
Support type: Scholarships in Brazil - Post-Doctorate