Poly(vinylidene-trifluoroethylene)/barium titanate composite for in vivo support of bone formation

Author(s)

Lopes, Helena B. ^[1] ; Santos, Thiago de S. ^[1] ; de Oliveira, Fabiola S. ^[1] ; Freitas, Gileade P. ^[1] ; de Almeida, Adriana L. G. ^[1] ; Gimenes, Rossano ^[2] ; Rosa, Adalberto L. ^[1] ; Beloti, Marcio M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Cell Culture Lab, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Itajuba, Inst Chem & Phys, Itajuba, MG - Brazil

• Document type: Journal article
• Source: JOURNAL OF BIOMATERIALS APPLICATIONS; v. 29, n. 1, p. 104-112, JUL 2014.
• Web of Science Citations: 14

Abstract

In this study, we evaluated the effect of poly(vinylidene fluoride-trifluoroethylene)/barium titanate (P(VDF-TrFE)/BT) membrane on in vivo bone formation. Rat calvarial bone defects were implanted with P(VDF-TrFE)/BT and polytetrafluoroethylene (PTFE) membranes, and at 4 and 8 weeks, histomorphometric and gene expression analyses were performed. A higher amount of bone formation was noticed on P(VDF-TrFE)/BT compared with PTFE. The gene expression of RUNX2, bone sialoprotein, osteocalcin, receptor activator of nuclear factor-kappa B ligand, and osteoprotegerin indicates that P(VDF-TrFE)/BT favored the osteoblast differentiation compared with PTFE. These results evidenced the benefits of using P(VDF-TrFE)/BT to promote new bone formation, which may represent a promising alternative to be employed in guided bone regeneration. (AU)

• FAPESP's process: 11/13623-0 - Effect of the Poly(Vinylidene-Trifluoroethylene)/Barium Titanate Membrane on the Bone Formation in Rat Cavariae Defects
• Grantee: Helena Bacha Lopes
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 11/10658-8 - Effect of the poly(vinylidene-trifluoroethylene)/barium titanate membrane on the bone formation in rat cavariae defects
• Grantee: Márcio Mateus Beloti
• Support Opportunities: Regular Research Grants