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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

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Spadotto, Raquel [1] ; Damasceno, Debora Cristina [2] ; Godinho, Antonio Francisco [3] ; Porto Amorim, Elaine Manoela [4] ; Perobelli, Juliana Elaine [5] ; Kempinas, Wilma De Grava [6]
Total Authors: 6
[1] Univ Estadual Paulista Unesp, Grad Program Geral & Appl Biol, Inst Biosci, Sao Paulo - Brazil
[2] UNESP, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP - Brazil
[3] Inst Biosci, Ctr Assistencia Toxicol, Sao Paulo - Brazil
[4] Univ Estadual Oeste Parana Unioeste, Ctr Biol & Hlth Sci CCBS, Cascavel, PR - Brazil
[5] Univ Estadual Campinas Unicamp, Grad Program Cellular & Struct Biol, Inst Biol, Campinas, SP - Brazil
[6] UNESP, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 56, n. 2, p. 96-103, MAR 2012.
Web of Science Citations: 4

Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries.; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. Arq Bras Endocrinol Metab. 2012;56(2):96-103 (AU)