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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects

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de Almeida, Amanda Roberta [1, 2] ; Monte-Alegre, Sarah [1, 2] ; Zanini, Michele Bianca [1, 2] ; Souza, Aglecio Luiz [1, 2] ; Etchebehere, Mauricio [1, 2] ; Rocha Gontijo, Jose Antonio [1, 2]
Total Authors: 6
[1] Univ Estadual Campinas, Lab Metab Hidrossalino, Disciplina Med Interna, BR-13083592 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, BR-13083592 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRITION & METABOLISM; v. 11, JUN 2 2014.
Web of Science Citations: 9

Background: Obesity is associated with development of the cardiorenal metabolic syndrome, which is a constellation of risk factors, such as insulin resistance, inflammatory response, dyslipidemia, and high blood pressure that predispose affected individuals to well-characterized medical conditions such as diabetes, cardiovascular and kidney chronic disease. The study was designed to establish relationship between metabolic and inflammatory disorder, renal sodium retention and enhanced blood pressure in a group of obese subjects compared with age-matched, lean volunteers. Methods: The study was performed after 14 h overnight fast after and before OGTT in 13 lean (BMI 22.92 +/- 2.03 kg/m(2)) and, 27 obese (BMI 36.15 +/- 3.84 kg/m(2)) volunteers. Assessment of HOMA-IR and QUICKI index were calculated and circulating concentrations of TNF-alpha, IL-6 and C-reactive protein, measured by immunoassay. Results: The study shows that a hyperinsulinemic (HI: 10.85 +/- 4.09 mu g/ml) subgroup of well-characterized metabolic syndrome bearers-obese subjects show higher glycemic and elevated blood pressure levels when compared to lean and normoinsulinemic (NI: 5.51 +/- 1.18 mu g/ml, P < 0.027) subjects. Here, the combination of hyperinsulinemia, higher HOMA-IR (HI: 2.19 +/- 0.70 (n = 12) vs. LS: 0.83 +/- 0.23 (n = 12) and NI: 0.98 +/- 0.22 (n = 15), P < 0.0001) associated with lower QUICKI in HI obese when compared with LS and NI volunteers (P < 0.0001), suggests the occurrence of insulin resistance and a defect in insulin-stimulated peripheral action. Otherwise, the adiponectin measured in basal period was significantly enhanced in NI subjects when compared to HI groups (P < 0.04). The report also showed a similar insulin-mediated reduction of post-proximal urinary sodium excretion in lean (LS: 9.41 +/- 0.68% vs. 6.38 +/- 0.92%, P = 0.086), and normoinsulinemic (NI: 8.41 +/- 0.72% vs. 5.66 +/- 0.53%, P = 0.0025) and hyperinsulinemic obese subjects (HI: 8.82 +/- 0.98% vs. 6.32 +/- 0.67%, P = 0.0264), after oral glucose load, despite elevated insulinemic levels in hyperinsulinemic obeses. Conclusion: In conclusion, this study highlights the importance of adiponectin levels and dysfunctional inflammatory modulation associated with hyperinsulinemia and peripheral insulin resistance, high blood pressure, and renal dysfunction in a particular subgroup of obeses. (AU)

FAPESP's process: 09/52325-5 - Effects of moderate intensity chronic physical exercise on the insulin signaling pathways, inflammation and oxidative stress in morbidly obese patients
Grantee:Sarah Monte Alegre
Support type: Regular Research Grants