Standardization of Resistance Exercise Training: Effects in Diabetic Ovariectomized Rats

Author(s)

Sanches, I. C. ^[1] ; Conti, F. F. ^[2] ; Sartori, M. ^[3] ; Irigoyen, M. C. ^[4] ; De Angelis, K. ^[5]

Affiliation

^[1] Univ Nove Julho UNINOVE. Lab Translat Physiol

^[2] Univ Nove Julho UNINOVE. Lab Translat Physiol

^[3] Univ Sao Paulo. Sch Med

^[4] Univ Sao Paulo. Sch Med

^[5] Univ Nove Julho UNINOVE. Lab Translat Physiol

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 35, n. 4, p. 323-329, APR 2014.
• Web of Science Citations: 17

Abstract

This study was carried out with a 3-fold aim: 1) to standardize a maximal load test (MLT) on ladders for prescription of resistance exercise training (RET) in rats, 2) to prescribe moderate-intensity RET based on this MLT and 3) to test the effect of this RET in diabetic ovariectomized rats. Female Wistar rats were divided into control (C), diabetic ovariectomized sedentary (DOS) and trained (DOT) groups. The MLT was standardized with increased load applied to the rat tail for each climb, and blood lactate was measured to identify lactate threshold in C rats. MLT was applied in the 1(st), 4(th) and 8(th) week of the protocol. After 8 weeks of RET, the arterial pressure was directly recorded. DOS group reduced performance in MLT, body weight, left ventricular, plantar and soleus muscles mass (vs. C). DOT rats showed an improvement in MLT associated with plantar muscle mass increased (vs. C and DOS), with attenuation of hypotension and bradycardia (vs. DOS). In conclusion, the results provide a useful method for determining the maximal load and applying RET in rats. Moreover, this study showed that moderate intensity RET improves hemodynamic status in diabetic ovariectomized rats, thereby reinforcing the role of RET in diabetes management. (AU)

• FAPESP's process: 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants