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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transmission of intra-cellular genetic information: A system proposal

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Faria, L. C. B. [1] ; Rocha, A. S. L. [1] ; Palazzo, Jr., R. [1]
Total Authors: 3
[1] Univ Estadual Campinas, Dept Commun, BR-13083852 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Theoretical Biology; v. 358, p. 208-231, OCT 7 2014.
Web of Science Citations: 3

One of the great challenges of the scientific community on theories of genetic information, genetic communication and genetic coding is to determine a mathematical structure related to DNA sequences. In this paper we propose a model of an intra-cellular transmission system of genetic information similar to a model of a power and bandwidth efficient digital communication system in order to identify a mathematical structure in DNA sequences where such sequences are biologically relevant. The model of a transmission system of genetic information is concerned with the identification, reproduction and mathematical classification of the nucleotide sequence of single stranded DNA by the genetic encoder. Hence, a genetic encoder is devised where labelings and cyclic codes are established. The establishment of the algebraic structure of the corresponding codes alphabets, mappings, labelings, primitive polynomials (p(x)) and code generator polynomials (g(x)) are quite important in characterizing error-correcting codes subclasses of G-linear codes. These latter codes are useful for the identification, reproduction and mathematical classification of DNA sequences. The characterization of this model may contribute to the development of a methodology that can be applied in mutational analysis and polymorphisms, production of new drugs and genetic improvement, among other things, resulting in the reduction of time and laboratory costs. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 05/54618-9 - Deciphering the molecular mechanisms involved in intracell location of proteins in plants
Grantee:Márcio de Castro Silva Filho
Support type: Research Projects - Thematic Grants