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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Update on infections and vaccinations in systemic lupus erythematosus and Sjogren's syndrome

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Pasoto, Sandra G. [1] ; Ribeiro, Ana C. M. [1] ; Bonfa, Eloisa [1]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: CURRENT OPINION IN RHEUMATOLOGY; v. 26, n. 5, p. 528-537, SEP 2014.
Web of Science Citations: 17

Purpose of review To provide an update on infections in systemic lupus erythematosus (SLE) and Sjogren's syndrome, particularly addressing their role as triggers of autoimmunity, their impact on mortality, the main microorganisms, the approaches to differential diagnosis with disease flares and recommendations for vaccination. Recent findings New mechanisms for autoimmunity triggered by Epstein-Barr virus and human commensal microbiota have been described. The increased risk for tuberculosis was recently demonstrated for the first time in Sjogren's syndrome. C-reactive protein was reported to be a more sensitive and specific marker for bacterial infections in SLE than procalcitonin and phagocyte-specific S100A8/A9 protein. Inactivated vaccines are well tolerated and efficacy was demonstrated for influenza vaccine. Immunogenicity is generally reduced but adequate in SLE. Prednisone or immunosuppressants are associated with decreased vaccine serological response, whereas hydroxicloroquine seems to improve vaccine immunogenicity. Other infection-preventive measures for these diseases include antimalarials and prophylaxis for tuberculosis or Pneumocystis jirovecii. Summary Advances in the role of infectious agents as triggers for SLE and Sjogren's syndrome have provided new insights into disease development. Knowledge on vaccine immunogenicity, safety and efficacy has improved with evidence of a generally reduced but adequate response for inactivated vaccines in SLE. Other preventive measures comprise infection prophylaxis and antimalarials. (AU)

FAPESP's process: 10/10013-4 - Serum autoantibodies in primary Sjögren's syndrome: study of clinical associations and possible correlations with antibodies to viral antigens (EBV and HTLV-1)
Grantee:Sandra Gofinet Pasoto
Support type: Regular Research Grants