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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship between gut hormones and glucose homeostasis after bariatric surgery

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Author(s):
Sala, Priscila Campos [1] ; Torrinhas, Raquel Susana [1] ; Giannella-Neto, Daniel [2] ; Waitzberg, Dan Linetzky [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Gastroenterol, Sch Med, Digest Surg Discipline LIM 35, BR-01246903 Sao Paulo - Brazil
[2] Univ Nove de Julho, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: DIABETOLOGY & METABOLIC SYNDROME; v. 6, AUG 16 2014.
Web of Science Citations: 18
Abstract

Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective treatment for severely obese patients. After bariatric surgery, T2D patients have shown a significant improvement in glycemic control, even before substantial weight loss and often discontinuation of medication for diabetes control. A central role for enteroendocrine cells from the epithelium of the gastrointestinal tract has been speculated in this postoperative phenomenon. These cells produce and secrete polypeptides - gut hormones - that are associated with regulating energy intake and glucose homeostasis through modulation of peripheral target organs, including the endocrine pancreas. This article reviews and discusses the biological actions of the gut hormones ghrelin, cholecystokinin, incretins, enteroglucagon, and Peptide YY, all of which were recently identified as potential candidates for mediators of glycemic control after bariatric surgery. In conclusion, current data reinforce the hypothesis that T2D reversion after bariatric surgery may be related to glycemic homeostasis developed by the intestine. (AU)

FAPESP's process: 13/03246-0 - Genomic, proteomic and metabolomic study of gastrointestinal tissue for patients with type 2 Diabetes mellitus after Roux-en-Y gastric bypass
Grantee:Priscila Sala Kobal
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass
Grantee:Dan Linetzky Waitzberg
Support type: Research Projects - Thematic Grants