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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia

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Amaral, Fernanda G. [1] ; Turati, Ariane O. [1] ; Barone, Mark [2] ; Scialfa, Julieta H. [1] ; Buonfiglio, Daniella do Carmo [1] ; Peres, Rafael [1] ; Peliciari-Garcia, Rodrigo A. [1] ; Afeche, Solange C. [3] ; Lima, Larissa [4] ; Scavone, Cristoforo [4] ; Bordin, Silvana [1] ; Reiter, Russel J. [5] ; Menna-Barreto, Luiz [2] ; Cipolla-Neto, Jose [1]
Total Authors: 14
[1] Univ Sao Paulo, Dept Physiol & Biophys, Neurobiol Lab, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508000 Sao Paulo - Brazil
[3] Butantan Inst, Pharmacol Lab, Sao Paulo - Brazil
[4] Univ Sao Paulo, Lab Mol Neuropharmacol, Dept Pharmacol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[5] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX - USA
Total Affiliations: 5
Document type: Journal article
Source: Journal of Pineal Research; v. 57, n. 1, p. 67-79, AUG 2014.
Web of Science Citations: 26

Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and health maintenance. It is crucial for energy metabolism regulation, and the diabetes effects on its synthesis are unresolved. Using diverse techniques that included pineal microdialysis and ultrahigh-performance liquid chromatography, the present data show a clear acute and sustained melatonin synthesis reduction in diabetic rats as a result of pineal metabolism impairment that is unrelated to cell death. Hyperglycemia is the main cause of several diabetic complications, and its consequences in terms of melatonin production were assessed. Here, we show that local high glucose (HG) concentration is acutely detrimental to pineal melatonin synthesis in rats both in vivo and in vitro. The clinically depressive action of high blood glucose concentration in melatonin levels was also observed in type 1 diabetes patients who presented a negative correlation between hyperglycemia and 6-sulfatoxymelatonin excretion. Additionally, high-mean-glycemia type 1 diabetes patients presented lower 6-sulfatoxymelatonin levels when compared to control subjects. Although further studies are needed to fully clarify the mechanisms, the present results provide evidence that high circulating glucose levels interfere with pineal melatonin production. Given the essential role played by melatonin as a powerful antioxidant and in the control of energy homeostasis, sleep and biological rhythms and knowing that optimal glycemic control is usually an issue for patients with diabetes, melatonin supplementation may be considered as an additional tool to the current treatment. (AU)

FAPESP's process: 09/52920-0 - Melatonin and the control of energy metabolism: central and peripheral actions and the circadian timing of the metabolic function
Grantee:José Cipolla Neto
Support type: Research Projects - Thematic Grants
FAPESP's process: 08/11026-2 - Sleep / wake cycle in diabetes mellitus type 1 subjects
Grantee:Luiz Silveira Menna Barreto
Support type: Regular Research Grants
FAPESP's process: 04/06767-2 - Melatonin and the control of energy metabolism: central and peripheral actions and their interaction with other hormones
Grantee:José Cipolla Neto
Support type: Research Projects - Thematic Grants