DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

Author(s)

Moreli, Jusciele Brogin ^[1] ; Santos, Janine Hertzog ^[2] ; Rocha, Clarissa Ribeiro ^[3] ; Damasceno, Debora Cristina ^[1] ; Morceli, Glilciane ^[1] ; Rudge, Marilza Vieira ^[1] ; Bevilacqua, Estela ^[4] ; Paranhos Calderon, Iracema Mattos ^{[1, 5]}

Affiliation

^[1] Sao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo - Brazil

^[2] NIEHS, Mol Carcinogenesis Lab, Durham, NC - USA

^[3] Univ Sao Paulo, Dept Microbiol, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil

^[5] Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP - Brazil

• Document type: Review article
• Source: BIOMED RESEARCH INTERNATIONAL; 2014.
• Web of Science Citations: 12

Abstract

The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA. (AU)

• FAPESP's process: 11/18240-2 - Association between oxidative stress, DNA damage and its cellular response in pregnant women and newborns at different hyperglycemia levels
• Grantee: Iracema de Mattos Paranhos Calderon
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/23296-0 - Damage in nuclear and Mitochondrial DNA in pregnant women and newborns at different hyperglycemia levels
• Grantee: Jusciele Brogin Moreli
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 11/13562-1 - Dna damage and its cellular response in pregnant women and newborns at different hyperglycemia levels
• Grantee: Jusciele Brogin Moreli
• Support Opportunities: Scholarships in Brazil - Doctorate