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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiological characteristics of chlorophyll a derivatives as microbial PDT agents

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Uliana, Marciana P. [1, 2] ; Pires, Layla [1] ; Pratavieira, Sebastiao [1] ; Brocksom, Timothy J. [2] ; de Oliveira, Kleber T. [2] ; Bagnato, Vanderlei S. [1] ; Kurachi, Cristina [1]
Total Authors: 7
[1] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 13, n. 8, p. 1137-1145, 2014.
Web of Science Citations: 19

Chlorin-e6 (chl-e6) and a hydrogenated derivative (chl-e6H) were semi-synthesized, and their photophysical properties and photodynamic activity against Escherichia coli, Staphylococcus aureus and Candida albicans evaluated. Methyl pheophorbide-a (Mepheo-a) was obtained from S. maxima using methanolic extraction with acid catalysis (CH3OH-H2SO4). Chlorin-e6 was prepared from Mepheo-a by basic hydrolysis with H2O-acetone and NaOH. Hydrogenated Chlorin-e6 was synthesized by a similar procedure starting from the hydrogenated methyl pheophorbide-a (Mepheo-aH). Photophysical studies were performed in order to determine the singlet oxygen quantum yield of chl-e6H which is higher than that of chl-e6. The microorganism inactivation of chl-e6 and chl-e6H was investigated at two concentrations and three fluence levels. Both chl-e6 and chl-e6H showed microorganism inactivation against Gram-positive bacteria and a fungus. (AU)

FAPESP's process: 11/19720-8 - Synthesis and Photodynamic Activity of New photosensitizers derived from porphyrinoids natural products
Grantee:Marciana Peirina Uliana
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
Grantee:Timothy John Brocksom
Support type: Regular Research Grants
FAPESP's process: 08/57858-9 - National Institute for Optics and Photonics
Grantee:Vanderlei Salvador Bagnato
Support type: Research Projects - Thematic Grants
FAPESP's process: 98/14270-8 - Center for Optical and Photonics Science
Grantee:Vanderlei Salvador Bagnato
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/06532-4 - Cross-coupling reactions on the synthesis of new photosensitizers with high conjugation
Grantee:Kleber Thiago de Oliveira
Support type: Regular Research Grants
FAPESP's process: 09/17476-2 - Assembly and characterization of an optical microscope for non-linear images of biological systems
Grantee:Sebastião Pratavieira
Support type: Scholarships in Brazil - Doctorate