Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas

• Processo: 18/07366-4
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Data de Início da vigência: 01 de abril de 2019
• Data de Término da vigência: 31 de março de 2025
• Área do conhecimento: Ciências Biológicas - Farmacologia - Farmacologia Bioquímica e Molecular
• Pesquisador responsável: Alexander Henning Ulrich
• Beneficiário: Alexander Henning Ulrich
• Instituição Sede: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Pesquisadores principais:( Últimos ): Luiz Roberto Giorgetti de Britto
• Pesquisadores principais:( Antigos ): Marimélia Aparecida Porcionatto
• Pesquisadores associados: Beatriz de Oliveira Monteiro ; Claudiana Lameu ; Cristiane Otero Reis Salum ; João Bosco Pesquero ; Luiz Henrique Catalani ; Marimélia Aparecida Porcionatto ; Mayana Zatz ; Roberto De Pasquale ; Roberto Kopke Salinas ; Silvana Chiavegatto
• Bolsa(s) vinculada(s): 24/22717-9 - Efeito do receptor P2X7 no neurodesenvolvimento cortical do modelo de autismo a partir da ativação imune materna (MIA), BP.DR; 24/17387-0 - Papel dos receptores purinérgicos P2X7 e P2Y12 no neurodesenvolvimento dos Transtornos do espectro autista e da Doença de Alzheimer: Integração de modelos de organoides cerebrais e camundongos, BP.PD; 24/17556-6 - Papel de receptores purinérgicos em modelo animal de imaturação hipocampal, BP.DD; + mais bolsas vinculadas 24/17748-2 - Avaliação do comportamento social em modelo murino de imaturação hipocampal, BP.IC; 24/04616-0 - Inibição do receptor purinérgico P2X7 na neuroinflamação mediada pela microglia no modelo in vivo da doença de Alzheimer e sua possível correlação com a GSK3, BP.IC; 24/04690-6 - O efeito da cafeína e da sinalização purinérgica em modelos tridimensionais da Doença de Alzheimer utilizando bioprinting, BP.PD; 23/09308-0 - Avaliação da modulação in vitro de receptores purinérgicos P2Y6, P2Y12 e P2X7 em linhagem microglial, BP.IC; 23/04077-0 - Estudo da co-morbidade do Transtorno Bipolar e Doença de Alzheimer utilizando culturas 3D de matrizes cerebrais descelularizadas., BP.TT; 23/06673-9 - Papel dos receptores purinérgicos e huntingtin na gastrulação., BP.TT; 22/10950-5 - Seleção e avaliação de proteínas e mecanismos fundamentais para a formação de memória de longo prazo, BP.DD; 22/09277-4 - Plasticidade patológica hipocampal na anóxia neonatal, BP.PD; 22/10616-8 - Avaliação da memória espacial, cognição e aprendizagem em modelo murino de imaturação hipocampal, BP.IC; 22/12888-5 - Papel do receptor purinérgico P2X7 na neurotoxicidade mediada pela microglia em modelos da doença de Alzheimer e sua possível correlação com a modulação da neurogênese, BP.IC; 22/01304-2 - Estudo in vitro do papel do receptor P2X4 em microglia sobre os processos inflamatórios envolvidos na doença de Parkinson, BP.MS; 21/01478-8 - Efeitos moleculares da modulação farmacológica dos receptores P2Y6 em modelo in vitro para estudo da Doença de Alzheimer, BP.MS; 21/04769-3 - Sinalização purinérgica mediada por exossomos na plasticidade do microambiente tumoral e quimiorresistência do Neuroblastoma, BP.DD; 21/00060-0 - Papel da modulação do receptor P2Y14 na resposta neuroinflamatória hipocampal em modelos in vitro e in vivo de Doença de Alzheimer, BP.PD; 21/05279-0 - Papel dos receptores purinérgicos e huntingtin na gastrulação., BP.TT; 21/04174-0 - Estudo da comorbidade do Transtorno Bipolar e Doença de Alzheimer utilizando culturas 3D de matrizes cerebrais descelularizadas, BP.TT; 20/10725-6 - Avaliação dos receptores de purinérgicos na comorbidade do transtorno bipolar e da Doença de Alzheimer, BP.DD; 20/07609-4 - Estudo do processo de neurorregeneração desencadeados pela Bradicinina no modelo animal da Doença de Parkinson, BP.IC; 19/24553-5 - O papel do receptor P2Y1 na Doença de Parkinson, BP.DR; 19/26852-0 - Estudo do antagonismo de receptores purinérgicos no processo inflamatório e ativação microglial em modelos in vivo e in vitro de Doença de Parkinson, BP.PD; 18/17504-5 - Efeitos comportamentais e moleculares da modulação farmacológica dos receptores P2Y2 em modelo animal da Doença de Alzheimer, BP.PD; 19/03494-0 - Silenciamento dos receptores de cininas B1R e B2R na linhagem celular microglial BV-2 como modelo de respostas neuroinflamatórias, BP.IC; 15/15826-7 - Hidrogel de colágeno modificado por proteína recombinante bi-funcional para o transplante de células tronco neurais para o tratamento de doenças neurodegenerativas, BP.PD; 15/19478-3 - Papel do receptor B2 de cininas na patogênese e progressão da doença de Alzheimer família experimental: da neurogênese e resposta imune à cognição, BP.PD; 15/13345-1 - Doença de Huntington: envolvimento de Huntingtin no controle do comprometimento celular, BP.PD - menos bolsas vinculadas
• Assunto(s): Doença de Alzheimer Doença de Parkinson Doença de Huntington Neurociências Bradicinina
• Palavra(s)-Chave do Pesquisador: bradicinina | Doença de Alzheimer | Doença De Huntington | Doença de Parkinson | sinalização por ATP | Neurociência

Resumo

O processo de neurogênese, que consiste na diferenciação de células tronco neurais (CTN) em neurônios, ocorre tanto na fase embrionária como no cérebro adulto. Por esse motivo, CTN têm sido sugeridas como importantes ferramentas para a regeneração de tecidos nervosos e reestabelecimento de condições saudáveis e para estudo para a compreensão do desenvolvimento fisiopatológico de diversas doenças neurológicas. Em trabalhos anteriores, nosso grupo demonstrou diferentes vias sinalizadoras que controlam o desenvolvimento de CTN, destacando-se o papel dos sistemas purinérgico e cininérgico, cuja modulação é essencial na determinação do fenótipo neural. Além de participar da neurotransmissão no cérebro adulto em condições saudáveis, sua modulação pode reverter quadros patológicos em modelos animais e in vitro das doenças de Parkinson e Alzheimer. Considerando os achados de nosso grupo, nesse projeto propomos uma investigação mais aprofundada sobre os mecanismos que permeiam essa modulação, a fim de elucidar como os sistemas de sinalização via purinas e cininas estão envolvidos e podem ser alvos terapêuticos para reverter patologias neurológicas especialmente associadas à neurodegeneração/ regeneração e aos processos neuroinflamatórios. Assim, o papel neurogênico, neuroprotetor e imunoregulatório da sinalização purinérgica e cininérgica será estudado nas doenças de Parkinson, Alzheimer, Huntington e no transtorno bipolar. Além disso, novas ferramentas baseadas em nanotecnologia, como biopolímeros conjugados à bradicinina, serão utilizadas no aprimoramento da técnica de transplante de CTN como alternativa terapêutica em modelos animais. (AU)

Publicações científicas

(85)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

WANG, TAO; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. Optical control of purinergic signaling. PURINERGIC SIGNALLING, JUN 2021. (18/07366-4)

VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 `-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 621-630, FEB 2020. (14/07248-0, 12/50880-4, 18/24678-0, 12/06633-2, 18/07366-4, 13/07937-8, 18/06381-0)

GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, APR 2020. (10/50554-4, 18/07366-4, 12/50880-4, 15/13345-1)

PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, SI, JAN 2021. (18/07366-4, 20/10725-6, 12/50880-4, 19/24553-5, 19/26852-0)

KRUGER, ARNE; DE JESUS SANTOS, ANA PAULA; DE SA, VANESSA; ULRICH, HENNING; WRENGER, CARSTEN. Aptamer Applications in Emerging Viral Diseases. PHARMACEUTICALS, v. 14, n. 7, JUL 2021. (18/07366-4, 15/26722-8, 17/03966-4, 15/26642-4)

DO NASCIMENTO, RAVENA PEREIRA; DOS SANTOS, BALBINO LINO; AMPARO, JESSIKA ALVES OLIVEIRA; SOARES, JANAINA RIBEIRO PEREIRA; DA SILVA, KARINA COSTA; SANTANA, MONIQUE REIS; ALMEIDA, AUREA MARIA ALVES NUNES; DA SILVA, VICTOR DIOGENES AMARAL; COSTA, MARIA DE FATIMA DIAS; ULRICH, HENNING; et al. euroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastom. PHARMACEUTICS, v. 14, n. 1, JAN 2022. (18/07366-4)

TOMCZYK, MARTA; GLASER, TALITA; SLOMINSKA, EWA M.; ULRICH, HENNING; SMOLENSKI, RYSZARD T.. Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 12, JUN 2021. (18/07366-4)

PILLAT, MICHELI MAINARDI; KRUGER, ARNE; FERREIRA GUIMARAES, LARA MENDES; LAMEU, CLAUDIANA; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; ULRICH, HENNING. Insights in Chloroquine Action: Perspectives and Implications in Malaria andCOVID-19. Cytometry Part A, v. 97, n. 9, AUG 2020. (18/07366-4, 18/08820-0, 15/26722-8, 15/19128-2)

ALAVARSE, ALEX CARVALHO; SILVA, JEAN BEZERRA; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Poly(vinyl alcohol)/sodium alginate/magnetite composites: magnetic force microscopy for tracking magnetic domains. SOFT MATTER, v. 19, n. 14, p. 11-pg., 2023-03-15. (18/13492-2, 18/07366-4, 20/01907-3, 19/08178-0)

REICHERT, KARINE P.; PILLAT, MICHELI M.; SCHETINGER, MARIA ROSA C.; BOTTARI, NATHIELI B.; PALMA, V, TAIS; ASSMANN, CHARLES E.; GUTIERRES, JESSIE M.; ULRICH, HENNING; ANDRADE, CINTHIA M.; EXLEY, CHRISTOPHER; et al. Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells. Chemosphere, v. 251, JUL 2020. (18/07366-4, 15/19478-3)

BOTTARI, NATHIELI B.; REICHERT, KARINE PAULA; FRACASSO, MATEUS; DUTRA, ANIELEN; ASSMANN, CHARLES ELIAS; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA M.; DA SILVA, ALEKSANDRO SCHAFER. Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii. Parasitology Research, v. 119, n. 9, p. 9-pg., 2020-07-17. (18/07366-4)

DE SOUZA, ANACLETO SILVA; AMORIM, VITOR MARTINS DE FREITAS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FELIPE R. C.; DOS SANTOS, FILIPE F.; DE SOUZA, ROBSON FRANCISCO; JUVENAL, GUILHERME DE ARAUJO; HUANG, YIHUA; GE, PINGJU; JIANG, YINAN; et al. Molecular Dynamics Analysis of Fast-Spreading Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Their Effects on the Interaction with Human Angiotensin-Converting Enzyme 2. ACS OMEGA, v. 7, n. 35, p. 10-pg., 2022-08-24. (20/06091-1, 17/18246-7, 17/19541-2, 20/04680-0, 19/00195-2, 16/09047-8, 18/15579-8, 18/07366-4, 20/14158-9)

ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. The P2X7 Receptor: Central Hub of Brain Diseases. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 13, JUL 31 2020. (15/13345-1, 18/17504-5, 19/24553-5, 15/19128-2, 18/07366-4)

CORREA-VELLOSO, JULIANA C.; BARTLETT, PAULA J.; BRUMER, ROBERT; GASPERS, LAWRENCE D.; ULRICH, HENNING; THOMAS, ANDREW P.. Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes. ISCIENCE, v. 24, n. 10, OCT 22 2021. (18/07366-4)

OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; ANDREJEW, ROBERTA; TURRINI, NATALIA; SILVA, JEAN BEZERRA; SACK, ULRICH; ULRICH, HENNING. Role of P2X7 Receptors in Immune Responses During Neurodegeneration. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, MAY 26 2021. (18/08426-0, 19/24553-5, 18/07366-4, 19/26852-0, 20/10725-6)

ARNAUD-SAMPAIO, VANESSA FERNANDES; ALVES RABELO, IZADORA LORRANY; ULRICH, HENNING; LAMEU, CLAUDIANA. The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis. STEM CELL REVIEWS AND REPORTS, v. 16, n. 2, p. 288-300, APR 2020. (15/19128-2, 18/07366-4, 17/06132-7)

CORREA-VELLOSO, JULIANA C.; LINARDI, ALESSANDRA M.; GLASER, TALITA; VELLOSO, FERNANDO J.; RIVAS, MARIA P.; LEITE, RENATA E. P.; GRINBERG, LEA T.; ULRICH, HENNING; AKINS, MICHAEL R.; CHIAVEGATTO, SILVANA; et al. Fmr1 exon 14 skipping in late embryonic development of the rat forebrain. BMC NEUROSCIENCE, v. 23, n. 1, p. 15-pg., 2022-05-31. (18/07366-4, 17/06100-8, 09/51297-8, 19/10868-4, 08/53857-8, 11/14329-9, 09/01333-8)

OLIVEIRA-GIACOMELLI, AGATHA; ALBINO, CAROLINA M.; NOBREGA DE SOUZA, HELLIO DANNY; CORREA-VELLOSO, JULIANA; DE JESUS SANTOS, ANA PAULA; BARANOVA, JULIANA; ULRICH, HENNING. P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, NOV 8 2019. (12/50880-4, 18/07366-4, 17/24400-9)

ARNAUD-SAMPAIO, VANESSA F.; RABELO, IZADORA L. A.; BENTO, CAROLINA A.; GLASER, TALITA; BEZERRA, JEAN; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. Using Cytometry for Investigation of Purinergic Signaling in Tumor-Associated Macrophages. Cytometry Part A, v. 97, n. 11, JUL 2020. (17/06132-7, 15/13345-1, 18/07366-4, 18/14993-5, 15/19128-2)

SEMEANO, ANA T.; TOFOLI, FABIANO A.; CORREA-VELLOSO, JULIANA C.; DE JESUS SANTOS, ANA P.; OLIVEIRA-GIACOMELLI, AGATHA; CARDOSO, RAFAELA R.; PESSOA, MATEUS A.; DA ROCHA, EDROALDO LUMMERTZ; RIBEIRO, GUSTAVO; FERRARI, MERARI F. R.; et al. Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells. STEM CELL REVIEWS AND REPORTS, v. 18, n. 4, p. 18-pg., 2022-03-24. (18/07366-4, 19/26852-0, 16/14513-8, 13/08028-1, 18/07592-4, 13/08135-2)

VILLEGAS, CECILIA; GONZALEZ-CHAVARRIA, IVAN; BURGOS, VIVIANA; ITURRA-BEIZA, HECTOR; ULRICH, HENNING; PAZ, CRISTIAN. Epothilones as Natural Compounds for Novel Anticancer Drugs Development. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 7, p. 20-pg., 2023-04-01. (18/07366-4)

SCHEUERMANN, KARINA; VIANA, CELSO TARSO RODRIGUES; DOS REIS, DIEGO CARLOS; DE LAZARI, MARCELA GUIMARAES TAKAHASHI; ORELLANO, LAURA ALEJANDRA ARIZA; MACHADO, CLARA TOLENTINO; DOS SANTOS, LETICIA CRISTINE CARDOSO; ULRICH, HENNING; CAPETTINI, LUCIANO SANTOS AGGUM; ANDRADE, SILVIA PASSOS; et al. Amitriptyline efficacy in decreasing implant-induced foreign body reaction. IUBMB Life, v. N/A, p. 11-pg., 2023-04-22. (18/07366-4)

PEREZ, REBECA; GLASER, TALITA; VILLEGAS, CECILIA; BURGOS, VIVIANA; ULRICH, HENNING; PAZ, CRISTIAN. Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment. LIFE-BASEL, v. 12, n. 12, p. 19-pg., 2022-12-01. (18/07366-4)

GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; RIBEIRO, DEIDIANE ELISA; ANDREJEW, ROBERTA; ULRICH, HENNING. Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases. FRONTIERS IN PHARMACOLOGY, v. 12, p. 7-pg., 2021-04-12. (18/08426-0, 18/17504-5, 19/24553-5, 19/26852-0, 15/13345-1, 18/07366-4)

PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, p. 12-pg., 2021-01-13. (12/50880-4, 20/10725-6, 19/24553-5, 19/26852-0, 18/07366-4)

DE SOUZA, ANACLETO SILVA; DE FREITAS AMORIM, VITOR MARTINS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FILIPE F.; ULRICH, HENNING; GALANTE, PEDRO A. F.; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains. Viruses-Basel, v. 14, n. 4, p. 21-pg., 2022-04-01. (18/07366-4, 20/06091-1, 19/00195-2, 16/09047-8, 20/14158-9, 20/04680-0, 17/18246-7, 17/19541-2, 18/15579-8)

CAVALCANTE, DANIEL PEREIRA; NUNES, ANTONIO ITALO DOS; DA SILVA, EDUARDO ROSA; DE CARVALHO, GUSTAVO ALMEIDA; CHIARELI, RAPHAELA ALMEIDA; OLIVEIRA-LIMA, ONESIA CRISTINA; ORTIZ-LEONCINI, GIOVANNI; ULRICH, HENNING; GOMEZ, RENATO SANTIAGO; PINTO, MAURO CUNHA XAVIER. GlyT1 inhibition promotes neuroprotection in the middle cerebral artery occlusion model through the activation of GluN2A-containing NMDAR. Experimental Neurology, v. 383, p. 13-pg., 2024-10-20. (18/07366-4)

ARNAUD-SAMPAIO, VANESSA FERNANDES; BENTO, CAROLINA ADRIANE; GLASER, TALITA; ADINOLFI, ELENA; ULRICH, HENNING; LAMEU, CLAUDIANA. P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma. FRONTIERS IN ONCOLOGY, v. 12, p. 19-pg., 2022-08-25. (18/07366-4, 15/19128-2)

BISSACOTTI, BIANCA FAGAN; COPETTI, PRISCILA MARQUEZAN; BOTTARI, NATHIELI BIANCHIN; PALMA, TAIS VIDAL; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO; MELCHIORS MORSCH, VERA MARIA; ULRICH, HENNING; DA SILVA, ALEKSANDRO SCHAFER. Curcumin modulates neurogliogenesis and purinergic receptor expression in neural precursor cells infected with Toxoplasma gondii. Parasitology Research, v. 122, n. 1, p. 8-pg., 2022-10-25. (18/07366-4)

PILLAT, MICHELI MAINARDI; AYUPE, ANA CAROLINA; JUVENAL, GUILHERME; MEINERZ, CARINE; GLASER, TALITA; DA SILVA PELLEGRINA, DIOGO VIEIRA; PAIVA, DAISYLEA SOUZA; MELLO, CARLOS FERNANDO; LONGO, BEATRIZ MONTEIRO; REIS, EDUARDO MORAES; et al. Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses. STEM CELL REVIEWS AND REPORTS, v. 19, n. 6, p. 12-pg., 2023-05-02. (18/07366-4, 18/08426-0)

F. FERREIRA, ANA FLAVIA; G. BRITTO, LUIZ ROBERTO. The transient receptor potential melastatin 2: a new therapeutical target for Parkinson's disease?. NEURAL REGENERATION RESEARCH, v. 18, n. 8, p. 5-pg., 2023-08-01. (18/07366-4, 20/02109-3)

YE, QING; LIN, SI-SI; ULRICH, HENNING; TANG, YONG. Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants. NEUROSCIENCE BULLETIN, v. 39, n. 8, p. 3-pg., 2023-03-28. (18/07366-4)

OLIVEIRA-LIMA, ONESIA CRISTINA; DE CARVALHO, GUSTAVO ALMEIDA; ASSUNCAO, LEANDRO DO PRADO; BAILAO, ALEXANDRE MELO; ULRICH, HENNING; MARQUES, BRUNO LEMES; DE OLIVEIRA, ANTONIO CARLOS PINHEIRO; GOMEZ, RENATO SANTIAGO; PINTO, MAURO CUNHA XAVIER. GlyT1 Inhibition by NFPS Promotes Neuroprotection in Amyloid-β-Induced Alzheimer's Disease Animal Model. Neurochemical Research, v. 49, n. 9, p. 21-pg., 2024-06-18. (18/07366-4, 18/08426-0)

SINGULANI, MONIQUE PATRICIO; FERREIRA, ANA FLAVIA FERNANDES; FIGUEROA, PAULINA SEPULVEDA; CUYUL-VASQUEZ, IVAN; TALIB, LEDA LEME; BRITTO, LUIZ ROBERTO; FORLENZA, ORESTES VICENTE. Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease. AGEING RESEARCH REVIEWS, v. 95, p. 20-pg., 2024-02-24. (20/02109-3, 18/07366-4, 21/06378-1, 14/50873-3)

ALAVARSE, ALEX C.; DA SILVA, RAFAEL L. C. G.; GHAFFARI BOHLOULI, PEJMAN; CORNEJO, DANIEL; ULRICH, HENNING; SHAVANDI, AMIN; PETRI, DENISE F. S.. Magnetic Force Microscopy and Nanoindentation on 3D Printed Magnetic Scaffolds for Neuronal Cell Growth. ACS APPLIED POLYMER MATERIALS, v. 6, n. 2, p. 12-pg., 2023-12-26. (19/22671-0, 20/01907-3, 22/08442-1, 18/07366-4, 18/13492-2)

FERREIRA, ANA FLAVIA F.; ULRICH, HENNING; FENG, ZHONG-PING; SUN, HONG-SHUO; BRITTO, LUIZ ROBERTO. Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model. Experimental Neurology, v. 377, p. 15-pg., 2024-04-25. (20/02109-3, 18/07366-4, 22/14820-9)

JUVENAL, GUILHERME; HIGA, GUILHERME SHIGUETO VILAR; BONFIM MARQUES, LUCAS; TESSARI ZAMPIERI, THAIS; COSTA VIANA, FELIPE JOSE; BRITTO, LUIZ R.; TANG, YONG; ILLES, PETER; DI VIRGILIO, FRANCESCO; ULRICH, HENNING; et al. Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease. PURINERGIC SIGNALLING, v. N/A, p. 29-pg., 2024-07-24. (22/00850-3, 22/09277-4, 18/07366-4, 22/10950-5)

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