Desenvolvimento de um sistema bidimensional de extração, separação e análise para avaliação da bioatividade de fitoquímicos

• Processo: 18/14582-5
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Data de Início da vigência: 01 de maio de 2019
• Data de Término da vigência: 30 de abril de 2025
• Área do conhecimento: Ciências Agrárias - Ciência e Tecnologia de Alimentos - Engenharia de Alimentos
• Pesquisador responsável: Maurício Ariel Rostagno
• Beneficiário: Maurício Ariel Rostagno
• Instituição Sede: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brasil
• Pesquisadores associados: Adriane Elisabete Antunes de Moraes ; Ana Carolina de Aguiar ; Augusto Ducati Luchessi ; Diogo Thimoteo da Cunha ; Fernando Moreira Simabuco ; Julian Martínez ; Rosângela Maria Neves Bezerra ; Tânia Forster Carneiro
• Vinculado ao auxílio: 13/04304-4 - Desenvolvimento de sistemas integrados para a análise de compostos bioativos em produtos naturais utilizando tecnologia supercrítica, AP.JP
• Auxílio(s) vinculado(s): 23/07411-8 - VI Iberoamerican Conference on Supercritical Fluids (PROSCIBA 2023), AR.EXT; 19/13496-0 - EMU aprovado no processo 2018/14582-5: sistema de cromatografia de ultra alta pressão (UHPLC), composto por bomba quaternária, injetor automático, forno com seletor de coluna, detector PDA, AP.EMU
• Bolsa(s) vinculada(s): 23/03439-5 - Extração, separação e análise bidimensional de compostos fenólicos de resíduos da agroindústria com potencial antimicrobiano contra Staphilococcus aureus para aplicação em curativos., BP.PD; 23/12744-6 - Avaliação de processo de termosonicação para extração de cafeína e ácido clorogênico de resíduo de café utilizando solventes alternativos, BP.IC; 23/11025-6 - Desenvolvimento de métodos de extração, separação e análise bidimensional de compostos fenólicos em produtos naturais, BP.PD; + mais bolsas vinculadas 23/05097-4 - Desenvolvimento de métodos de extração, separação e análise bidimensional de compostos fenólicos em produtos naturais, BP.PD; 22/10469-5 - Aplicação de ferramentas in silico para a extração de compostos bioativos de subprodutos agrícolas por meio de líquidos expandidos por gás e solventes alternáveis e verdes, BP.PD; 21/12264-9 - Avaliação técnico-econômica do acoplamento de tecnologias emergentes e de solventes verdes ao sistema bidimensional de extração, separação e análise para obtenção de composto fenólicos de resíduos da indústria de café e de bebidas vegetais, BP.PD; 21/13638-0 - Desenvolvimento de embalagem ativa através da extração de compostos bioativos da casca da romã (Punica granatum L.), BP.MS; 20/15774-5 - Desenvolvimento de métodos de extração, separação e análise bidimensional de compostos fenólicos em produtos naturais, BP.PD; 20/04067-6 - Avaliação da extração com líquidos pressurizados assistida por ultrassom acoplada à extração em fase sólida para a extração separação de compostos fenólicos e terpenos do alecrim (Rosmarinus officinalis) e sálvia (Salvia officinalis), BP.DD; 20/08421-9 - Aplicação de solventes alternativos não voláteis para criação de plataformas sustentáveis bidimensionais e integradas dos rejeitos agroindustriais dos frutos de jabuticaba e romã, BP.PD; 20/03623-2 - Extração e separação por um sistema bidimensional de compostos fenólicos a partir da própolis verde, BP.DD; 19/24537-0 - Avaliação de fitoquímicos do resíduo industrial de maçã (Malus domestica) a partir da extração e separação por um sistema bidimensional, BP.DD - menos bolsas vinculadas
• Assunto(s): Compostos bioativos Extração em fase sólida Produtos naturais
• Palavra(s)-Chave do Pesquisador: análise bidimensional | Compostos bioativos | cromatografia líquida de ultra alta pressão | Extração com liquidos pressurizados | Extração em fase sólida | Produtos Naturais | Extração e análise

Resumo

Este projeto de pesquisa propõe o desenvolvimento de um sistema de extração, separação e análise bidimensional (PLEgrad-SPE x UHPLC) através do acoplamento da extração com líquidos pressurizados em gradiente (PLEgrad) com a extração em fase sólida (SPE) na primeira dimensão e ortogonalmente com a cromatografia de ultra alta pressão (UHPLC) na segunda dimensão. Buscar-se desenvolver um sistema que permita a caracterização da composição química de matérias-primas naturais de forma rápida, eficiente e com monitoramento em tempo real enquanto permite a produção de pequenas quantidades de extratos obtidos através do fracionamento dos compostos presentes. Estas frações deverão ser bem caracterizadas quimicamente e com baixa contaminação entre as elas. O sistema será validado com diversas amostras, incluindo soja (Glycine max), ginseng brasileiro (Pfaffia glomerata), chá preto e chá verde, (Camellia sinensis), mate (Ilex paraguariensis), café (Coffea arabica), casca de romã (Punica granatum), casca de laranja (Citrus sinensis), casca de limão siciliano (Citrus x limon) casca de maça (Malus domestica), casca de jabuticaba (Myrciaria cauliflora), alecrim (Rosmarinus officinalis) e salvia (Salvia officinalis). Inicialmente serão desenvolvidos os métodos de análise rápidos por UHPLC que serão utilizados na segunda dimensão de separação. Serão avaliadas diversas condições de análise (temperatura, tamanho de coluna, fluxo, volume e solvente de injeção e composição de fase móvel) buscando um método ultrarrápido de separação (tempo entre amostras < 2,0 min). Posteriormente serão avaliadas diferentes condições de extração por PLE com gradiente acoplado à SPE, incluindo temperatura, pressão, quantidade de amostra, tipo de adsorvente, fluxo, solvente e duração do gradiente de extração/eluição. Esta proposta consiste em uma continuação do projeto Jovem Pesquisador (FAPESP 2013/04304-4) buscando a consolidação desta linha de pesquisa na FCA/UNICAMP e a continuação da formação de recursos humanos qualificados. (AU)

Publicações científicas

(65)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

LACHOS-PEREZ, DANIEL; BASEGGIO, ANDRESSA M.; TORRES-MAYANGA, PAULO C.; AVILA, PATRICIA F.; TOMPSETT, G. A.; MAROSTICA, MARIO; GOLDBECK, ROSANA; TIMKO, MICHAEL T.; ROSTAGNO, MAURICIO; MARTINEZ, JULIAN; et al. Sequential subcritical water process applied to orange peel for the recovery flavanones and sugars. JOURNAL OF SUPERCRITICAL FLUIDS, v. 160, JUN 1 2020. (18/14582-5, 18/05999-0, 11/19817-1, 16/04602-3)

SILVA, CAMILA TELLES; DA SOUZA, MARIANA CORREA; DA FONSECA MACHADO, ANA PAULA; DO NASCIMENTO, ROBERTO DE PAULA; DA CUNHA, DIOGO THIMOTEO; NEVES BEZERRA, ROSANGELA MARIA; ROSTAGNO, MAURICIO ARIEL. Thermal stability and sensory evaluation of a bioactive extract from roasted coffee (Coffea arabica) beans added at increasing concentrations to conventional bread. JOURNAL OF FOOD PROCESSING AND PRESERVATION, v. 45, n. 11, SEP 2021. (18/14582-5, 16/19930-6, 17/23657-6, 13/04304-4, 18/17089-8)

CHAVES, JAISA O.; SANCHES, VITOR L.; VIGANO, JULIANE; MESQUITA, LEONARDO M. DE SOUZA; DE SOUZA, MARIANA C.; DA SILVA, LAISE C.; ACUNHA, TANIZE; FACCIOLI, LUCIA H.; ROSTAGNO, MAURICIO A.. Integration of pressurized liquid extraction and in-line solid-phase extraction to simultaneously extract and concentrate phenolic compounds from lemon peel (Citrus limon L.). Food Research International, v. 157, p. 12-pg., 2022-07-01. (13/04304-4, 20/08421-9, 15/00658-1, 19/13496-0, 18/14582-5, 20/15774-5)

DA SILVA, LAISE C.; SOUZA, MARIANA C.; SUMERE, BEATRIZ R.; SILVA, LUIZ G. S.; DA CUNHA, DIOGO T.; BARBERO, GERARDO F.; BEZERRA, ROSANGELA M. N.; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of bioactive compounds from apple pomace using pressurized liquids coupled on-line with solid-phase extraction. Food Chemistry, v. 318, JUL 15 2020. (18/14582-5, 16/19930-6, 18/17089-8, 19/24537-0)

MACIEL-SILVA, FRANCISCO W.; BULLER, LUZ S.; GONCALVES, MARIA L. M. B. B.; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. ustainable development in the Legal Amazon: energy recovery from acai seed. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 15, n. 4, p. 1174-1189, JUL 2021. (18/14582-5, 18/14938-4, 20/10323-5, 18/05999-0)

BAIAO DIAS, ARTHUR LUIZ; DE AGUIAR, ANA CAROLINA; ROSTAGNO, MAURICIO A.. Extraction of natural products using supercritical fluids and pressurized liquids assisted by ultrasound: Current status and trends. ULTRASONICS SONOCHEMISTRY, v. 74, JUN 2021. (18/14582-5)

CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; SANCHES, VITOR L.; VIGANO, JULIANE; KAMIKAWACHI, RENAN CANUTE; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Ultra-high-performance liquid chromatography using a fused-core particle column for fast analysis of propolis phenolic compounds. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 3, p. 12-pg., 2022-12-09. (18/14582-5, 19/13496-0, 20/08421-9, 20/15774-5)

MACIEL-SILVA, FRANCISCO W.; VIGANO, JULIANE; CASTRO, LUIZ E. N.; SGANZERLA, WILLIAM GUSTAVO; BULLER, LUZ SELENE; MARTINEZ, JULIAN; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Pressurized liquid extraction coupled in-line with SPE and on-line with HPLC (PLE-SPExHPLC) for the recovery and purification of anthocyanins from SC-CO2 semi-defatted Acai (Euterpe oleracea). Food Research International, v. 160, p. 11-pg., 2022-07-26. (20/10323-5, 20/15774-5, 18/14938-4, 18/05999-0, 19/26925-7, 18/14582-5)

TORRES-MAYANGA, PAULO. C. C.; CASTRO, LUIZ E. N.; AZAMBUJA, SUELLEN P. H.; LACHOS-PEREZ, DANIEL; BROWN, AVERY. B. B.; TIMKO, MICHAEL. T. T.; GOLDBECK, ROSANA; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO. A. A.. Detoxification of furanic aldehydes of the hemicellulosic hydrothermal hydrolysate of brewers' spent grains by continuous adsorption on a fixed-bed column. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. N/A, p. 14-pg., 2023-02-10. (21/04096-9, 20/10323-5, 18/14938-4, 18/05999-0, 18/14582-5)

OLIVEIRA, T. C. G.; INTERLANDI, M. A.; HANLON, K. E.; TORRES-MAYANGA, P. C.; SILVELLO, M. A. C.; TIMKO, M. T.; ROSTAGNO, M. A.; GOLDBECK, R.; FORSTER-CARNEIRO, T.. Integration of Subcritical Water and Enzymatic Hydrolysis to Obtain Fermentable Sugars and Second-Generation Ethanol from Sugarcane Straw. BioEnergy Research, v. 15, n. 2, p. 12-pg., 2021-04-17. (19/08542-3, 18/05999-0, 18/14582-5, 13/04304-4, 18/14938-4)

BARROSO, TIAGO LINHARES CRUZ TABOSA; CASTRO, LUIZ EDUARDO NOCHI; DE SOUZA MESQUISTA, LEONARDO M.; BARBERO, GERARDO FERNANDEZ; CARRERA, CEFERINO; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Simple procedure for the simultaneous extraction and purification of anthocyanins using a jabuticaba byproduct biosorbent. Journal of Food Composition and Analysis, v. 130, p. 10-pg., 2024-03-29. (18/14938-4, 22/02039-0, 21/04096-9, 20/16248-5, 18/14582-5)

KESHMIRSHEKAN, ABOLFAZL; MESQUITA, LEONARDO M. DE SOUZA; VENTURA, SONIA P. M.. Biocontrol manufacturing and agricultural applications of Bacilus velezensis. TRENDS IN BIOTECHNOLOGY, v. 42, n. 8, p. 16-pg., 2024-08-07. (21/11022-1, 19/13496-0, 18/14582-5, 20/08421-9)

BARROSO, TIAGO LINHARES CRUZ TABOSA; CASTRO, LUIZ EDUARDO NOCHI; LIMA, JOSE ROMUALDO DE SOUSA; COLPINI, LEDA MARIA SARAGIOTTO; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Synthesis and Optimization of biosorbent using jabuticaba peel (Myrciaria cauliflora) for anthocyanin recovery through adsorption. ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY, v. 30, n. 6, p. 21-pg., 2024-05-18. (20/16248-5, 18/14582-5, 21/04096-9)

FRONER-LACERDA, LUANA R. R.; SGANZERLA, WILLIAM GUSTAVO; LACERDA, VINICIUS F.; SILLERO, LEONOR; SOLERA, ROSARIO; PEREZ, MONTSERRAT; FORSTER-CARNEIRO, TANIA. Design, fabrication, automation, and scaleup of anaerobic reactors for waste management and bioenergy recovery. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 18, n. 5, p. 14-pg., 2024-03-14. (18/14582-5)

VIGANO, JULIANE; STRIEDER, MONIQUE MARTINS; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.. Application of an integrative system (2D PLExHPLC-PDA) for bioactive compound extraction and online quantification: Advantages, validation, and considerations. Analytica Chimica Acta, v. 1272, p. 9-pg., 2023-06-15. (18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 21/12264-9, 20/03623-2, 20/04067-6)

BARROSO, TIAGO LINHARES CRUZ TABOSA; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; FREIRIA, NICOLAS LUIS MOREIRA; BARBERO, GERARDO FERNANDEZ; LOVILLO, MIGUEL PALMA; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Removal of 5-hydroxymethylfurfural from brewer's spent grains hydrolysates obtained by subcritical water hydrolysis: An approach using liquid-liquid extraction. JOURNAL OF SUPERCRITICAL FLUIDS, v. 201, p. 9-pg., 2023-06-13. (21/04096-9, 18/14582-5, 18/14938-4, 20/16248-5, 19/26925-7)

DE SOUZA MESQUITA, LEONARDO M.; CONTIERI, LETICIA S.; SOSA, FILIPE H. B.; PIZANI, RODRIGO S.; CHAVES, JAISA; VIGANO, JULIANE; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Combining eutectic solvents and pressurized liquid extraction coupled in-line with solid-phase extraction to recover, purify and stabilize anthocyanins from Brazilian berry waste. GREEN CHEMISTRY, v. 25, n. 5, p. 14-pg., 2023-02-21. (21/11022-1, 18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 20/03623-2, 21/11023-8, 20/04067-6)

SANCHES, VITOR L.; DE SOUZA MESQUITA, LEONARDO M.; VIGANO, JULIANE; CONTIERI, LETICIA S.; PIZANI, RODRIGO; CHAVES, JAISA; DA SILVA, LAISE CAPELASSO; DE SOUZA, MARIANA CORREA; BREITKREITZ, MARCIA CRISTINA; ROSTAGNO, MAURICIO A.. Insights on the Extraction and Analysis of Phenolic Compounds from Citrus Fruits: Green Perspectives and Current Status. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, v. N/A, p. 27-pg., 2022-08-16. (18/14582-5, 20/15774-5, 19/13496-0, 19/24537-0, 20/08421-9, 20/03623-2)

SANCHES, VITOR L.; STRIEDER, MONIQUE MARTINS; BREITKREITZ, MARCIA CRISTINA; BEZERRA, ROSANGELA MARIA NEVES; CHAVES, JAISA O.; DE OLIVEIRA, ISADORA LOPES; MESQUITA, LEONARDO M. DE SOUZA; VIGANO, JULIANE; CONTIERI, LETICIA SANCHES; PIZANI, RODRIGO STEIN; et al. Pressurized liquid extraction assisted by high-intensity ultrasound to obtain hesperidin from lime waste: Integration of in-line purification and on-line chromatographic analysis. Food Research International, v. 182, p. 9-pg., 2024-02-28. (20/08421-9, 19/24537-0, 20/03623-2, 19/13496-0, 21/13638-0, 18/14582-5)

MUSSAGY, CASSAMO U.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.; HADDAD, FELIPE F.; DOS SANTOS, JEAN L.; SCARIM, CAUE B.; HERCULANO, RONDINELLI D.; VALETTE, JEREMY; SANGARE, DIAKARIDIA. Eco-sustainable biorefinery to the management of winery waste by integrating sequential ready-to-use pigments and bioenergy through advanced multi-step kinetic slow pyrolysis. INDUSTRIAL CROPS AND PRODUCTS, v. 221, p. 12-pg., 2024-08-08. (19/13496-0, 18/14582-5, 20/08421-9)

MESQUITA, LEONARDO M. DE SOUZA; VIGANO, JULIANE; VEGGI, PRISCILLA; CONTIERI, LETICIA S.; SOSA, FILIPE H. B.; DE ROSSO, VERIDIANA VERA; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Techno-Economic analysis of an efficient anthocyanin extraction process from grape pomace using eutectic solvents ― A critical panorama regarding drying techniques and reusability of solvents. Separation and Purification Technology, v. 347, p. 9-pg., 2024-04-26. (20/15774-5, 21/11022-1, 20/08421-9, 20/03623-2, 19/13496-0, 16/18910-1, 21/11023-8, 18/14582-5)

FRANCISCO, ANA PAULA; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; BARROSO, TIAGO LINHARES CRUZ TABOSA; DA SILVA, ALINE PRISCILLA GOMES; DA ROSA, CLEONICE GONCALVES; NUNES, MICHAEL RAMOS; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO A.. Pressurized liquid extraction of bioactive compounds from grape peel and application in pH-sensing carboxymethyl cellulose films: A promising material to monitor the freshness of pork and milk. Food Research International, v. 179, p. 12-pg., 2024-01-19. (19/26925-7, 21/04096-9, 20/16248-5, 18/14582-5)

CHAVES, JAISA O.; MESQUITA, LEONARDO M. DE SOUZA; STRIEDER, MONIQUE M.; CONTIERI, LETICIA S.; PIZANI, RODRIGO S.; SANCHES, VITOR L.; VIGANO, JULIANE; BEZERRA, ROSANGELA M. NEVES; ROSTAGNO, MAURICIO A.. Eco-friendly and high-performance extraction of flavonoids from lemon peel wastes by applying ultrasound-assisted extraction and eutectic solvents. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 39, p. 13-pg., 2024-06-01. (20/15774-5, 15/00658-1, 20/08421-9, 13/04304-4, 19/13496-0, 19/13496-0, 18/14582-5)

MESQUITA, LEONARDO M. DE SOUZA; CONTIERI, LETICIA S.; A. E SILVA, FRANCISCA; BAGINI, RAFAEL HENRIQUE; BRAGAGNOLO, FELIPE S.; STRIEDER, MONIQUE M.; SOSA, FILIPE H. B.; SCHAEFFER, NICOLAS; FREIRE, MARA G.; VENTURA, SONIA P. M.; et al. Path2Green: introducing 12 green extraction principles and a novel metric for assessing sustainability in biomass valorization. GREEN CHEMISTRY, v. 26, n. 19, p. 21-pg., 2024-08-12. (20/15774-5, 21/11022-1, 15/00658-1, 20/08421-9, 13/04304-4, 23/12621-1, 22/10469-5, 20/03623-2, 19/13496-0, 21/11023-8, 21/12264-9, 18/14582-5, 23/05722-6)

COSTA, JOSIEL MARTINS; STRIEDER, MONIQUE MARTINS; SALDANA, MARLENY D. A.; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Recent Advances in the Processing of Agri-food By-products by Subcritical Water. Food and Bioprocess Technology, v. N/A, p. 20-pg., 2023-04-01. (18/14582-5, 18/14938-4, 21/12264-9, 21/03950-6)

NOCHI CASTRO, LUIZ EDUARDO; SGANZERLA, WILLIAM GUSTAVO; CRUZ TABOSA BARROSOA, TIAGO LINHARES; MACIEL-SILVA, FRANCISCO WESHLEY; SARAGIOTTO COLPINI, LEDA MARIA; STIVAL BITTENCOURT, PAULO RODRIGO; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Improving the semi-continuous flow-through subcritical water hydrolysis of grape pomace (Vitis vinifera L.) by pH and temperature control. JOURNAL OF SUPERCRITICAL FLUIDS, v. 196, p. 14-pg., 2023-02-28. (21/04096-9, 18/14582-5, 18/14938-4, 19/26925-7, 20/16248-5)

DE FREITAS MARINHO, LEONARDO; SGANZERLA, WILLIAM GUSTAVO; VELASQUEZ, JEAN AGUSTIN; DA SILVA, ALINE PRISCILLA GOMES; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. A bibliometric analysis of phenolic acids over the last five years. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 56, p. 13-pg., 2024-02-02. (19/26925-7, 18/14938-4, 22/11690-7, 21/08696-0, 18/14582-5)

DE OLIVEIRA, ISADORA LOPES; DOMINGUEZ-RODRIGUEZ, GLORIA; MONTERO, LIDIA; VIGANO, JULIANE; CIFUENTES, ALEJANDRO; ROSTAGNO, MAURICIO ARIAL; IBANEZ, ELENA. Advanced Extraction Techniques Combined with Natural Deep Eutectic Solvents for Extracting Phenolic Compounds from Pomegranate (Punica granatum L.) Peels. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 18, p. 16-pg., 2024-09-01. (22/13565-5, 18/14582-5, 21/13638-0)

MESQUITA, LEONARDO M. DE SOUZA; CONTIERI, LETICIA S.; SANCHES, VITOR L.; KAMIKAWACHI, RENAN; SOSA, FILIPE H. B.; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Fast and green universal method to analyze and quantify anthocyanins in natural products by UPLC-PDA. Food Chemistry, v. 428, p. 11-pg., 2023-12-01. (21/11022-1, 18/14582-5, 20/08421-9, 19/13496-0, 20/03623-2, 21/11023-8)

SANTANA, IGOR M.; ROSTAGNO, MAURICIO A.; BREITKREITZ, MARCIA C.. Analytical quality-by-design (AQbD) approach for comprehensive analysis of bioactive compounds from Citrus peel wastes by UPLC. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 415, n. 18, p. 12-pg., 2023-02-28. (18/14582-5)

CHAVES, JAISA OLIVEIRA; DE SOUZA, MARIANA CORREA; DA SILVA, LAISE CAPELASSO; LACHOS-PEREZ, DANIEL; TORRES-MAYANGA, PAULO CESAR; MACHADO, ANA PAULA DA FONSECA; FORSTER-CARNEIRO, TANIA; VAZQUEZ-ESPINOSA, MERCEDES; GONZALEZ-DE-PEREDO, ANA VELASCO; BARBERO, GERARDO FERNANDEZ; et al. Extraction of Flavonoids From Natural Sources Using Modern Techniques. RONTIERS IN CHEMISTR, v. 8, p. 25-pg., 2020-09-25. (18/17089-8, 18/05999-0, 18/14582-5, 16/19930-6, 18/14938-4)

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SOUZA, MARIANA C.; SILVA, LAISE C.; CHAVES, JAISA O.; SALVADOR, MAYARA P.; SANCHES, VITOR L.; DA CUNHA, DIOGO T.; CARNEIRO, TANIA FOSTER; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of compounds from mate (Ilex paraguariensis) leaves by pressurized liquid extraction coupled with solid-phase extraction and in-line UV detection. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 2, p. 11-pg., 2021-07-30. (19/24537-0, 18/14582-5, 13/04304-4, 16/19930-6)

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