Estudo de células neoplásicas por espectroscopia de infravermelho próximo

• Processo: 01/14384-8
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de junho de 2003
• Data de Término da vigência: 28 de fevereiro de 2009
• Área do conhecimento: Engenharias - Engenharia Biomédica - Bioengenharia
• Pesquisador responsável: Airton Abrahao Martin
• Beneficiário: Airton Abrahao Martin
• Instituição Sede: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brasil
• Município da Instituição Sede: São José dos Campos
• Assunto(s): Histopatologia Neoplasias mamárias Células tumorais Biópsia Espectroscopia Raman Espectroscopia infravermelha Diagnóstico clínico
• Palavra(s)-Chave do Pesquisador: Biopsia | Cancer De Mama | Celulas Meoplasicas | Diagnostico Nao Invasivo | Histopatologia

Resumo

O presente projeto visa à implantação de um laboratório de pesquisa para o estudo de células neoplásicas por espectroscopia Raman e de Infravermelho com transformada de Fourier. Pretendemos utilizar estas duas técnicas ópticas (complementares) para realizar um minucioso estudo dos modos vibracionais em tecidos das glândulas mamarias (câncer de mama) com o objetivo de diferenciar espectroscopicamente tecidos benignos de tecidos malignos (Biopsia Óptica). Num segundo estágio, utilizaremos um microscópio óptico, para estudarmos os processos evolutivos desta patologia no intuito de detectarmos transformações bioquímicas em seu estágio inicial de desenvolvimento. (AU)

Publicações científicas

(35)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

SOARES, L. E. S.; CAMPOS, A. D. F.; MARTIN, A. A.. Human and Bovine Dentin Composition and Its Hybridization Mechanism Assessed by FT-Raman Spectroscopy. JOURNAL OF SPECTROSCOPY, 2013. (01/14384-8)

NOGUEIRA, GRAZIELLE V.; SILVEIRA JUNIOR, LANDULFO; MARTIN, AIRTON ABRAHÃO; ZÂNGARO, RENATO A.; PACHECO, MARCOS T. T.; CHAVANTES, MARIA C.; PASQUALUCCI, CARLOS A.. Raman spectroscopy study of atherosclerosis in human carotid artery. Journal of Biomedical Optics, v. 10, n. 3, p. 00-00, May-June 2005. (01/14384-8)

PAULA, SHIRLEY DE SOUZA; SILVA SOARES, LUIS EDUARDO; DO ESPIRITO SANTO, ANA MARIA; MARTIN, AIRTON ABRAHAO; CAVALLI, VANESSA; SUZY LIPORONI, PRISCILA CHRISTIANE. FT-Raman and Energy Dispersive X-Ray Fluorescence Spectrometric Analyses of Enamel Submitted to 38% Hydrogen Peroxide Bleaching, an Acidic Beverage, and Simulated Brushing. Photomedicine and Laser Surgery, v. 28, n. 3, p. 391-396, JUN 2010. (01/14384-8)

LUÍS EDUARDO SILVA SOARES; ALDO BRUGNERA JUNIOR; FÁTIMA ZANIN; MARCOS TADEU TAVARES PACHECO; AIRTON A. MARTIN. Molecular analysis of Er:YAG laser irradiation on dentin. Brazilian Dental Journal, v. 17, n. 1, p. 15-19, 2006-00-00. (01/14384-8)

ISABEL CRISTINA CELERINO DE MORAES PORTO; LUIS EDUARDO SILVA SOARES; AIRTON ABRAHÃO MARTIN; VANESSA CAVALLI; PRISCILA CHRISTIANE SUZY LIPORONI. Influence of the photoinitiator system and light photoactivation units on the degree of conversion of dental composites. Brazilian Oral Research, v. 24, n. 4, p. 475-481, 2010-12-00. (01/14384-8)

GARCIA-FLORES, A. F.; RANIERO, L.; CANEVARI, R. A.; JALKANEN, K. J.; BITAR, R. A.; MARTINHO, H. S.; MARTIN, A. A.. High-wavenumber FT-Raman spectroscopy for in vivo and ex vivo measurements of breast cancer. THEORETICAL CHEMISTRY ACCOUNTS, v. 130, n. 4-6, p. 1231-1238, DEC 2011. (01/14384-8)

RANIERO, L.; CANEVARI, R. A.; RAMALHO, L. N. Z.; RAMALHO, F. S.; DOS SANTOS, E. A. P.; BITAR, R. A.; JALKANEN, K. J.; MARTINHO, H. S.; MARTIN, A. A.. In and ex vivo breast disease study by Raman spectroscopy. THEORETICAL CHEMISTRY ACCOUNTS, v. 130, n. 4-6, p. 1239-1247, DEC 2011. (01/14384-8)

DAINEZI, VANESSA BENETELLO; IWAMOTO, ALEXSANDRA SHIZUE; MARTIN, AIRTON ABRAHAO; SILVA SOARES, LUIS EDUARDO; HOSOYA, YUMIKO; PASCON, FERNANDA MIORI; PUPPIN-RONTANI, REGINA MARIA. Molecular and morphological surface analysis: effect of filling pastes and cleaning agents on root dentin. Journal of Applied Oral Science, v. 25, n. 1, p. 101-111, JAN-FEB 2017. (05/50811-9, 01/14384-8, 10/12757-0, 09/10837-0)

SILVA SOARES, LUIS EDUARDO; SILVA SOARES, ANA LUCIA; DE OLIVEIRA, RODRIGO; NAHORNY, SIDNEI. The Effects of Acid Erosion and Remineralization on Enamel and Three Different Dental Materials: FT-Raman Spectroscopy and Scanning Electron Microscopy Analysis. MICROSCOPY RESEARCH AND TECHNIQUE, v. 79, n. 7, p. 646-656, JUL 2016. (01/14384-8)

NUNES LEITE LIMA, DEBORA ALVES; BAGGIO AGUIAR, FLAVIO HENRIQUE; PAVESI PINI, NUBIA INOCENCYA; SILVA SOARES, LUIS EDUARDO; MARTIN, AIRTON ABRAHAO; SUZY LIPORONI, PRISCILA CHRISTIANE; BOVI AMBROSANO, GLAUCIA MARIA; LOVADINO, JOSE ROBERTO. In vitro effects of hydrogen peroxide combined with different activators for the in-office bleaching technique on enamel. ACTA ODONTOLOGICA SCANDINAVICA, v. 73, n. 7, p. 516-521, 2015. (01/14384-8, 05/60082-4)

SANDRINE BITTENCOURT BERGER; LUIS EDUARDO SILVA SOARES; AIRTON ABRAHÃO MARTIN; GLÁUCIA MARIA BOVI AMBROSANO; CÍNTHIA PEREIRA MACHADO TABCHOURY; MARCELO GIANNINI. Effects of various hydrogen peroxide bleaching concentrations and number of applications on enamel. Braz. J. Oral Sci., v. 13, n. 1, p. 22-27, 2014-03-00. (05/60696-2, 01/14384-8, 05/50811-9)

LUCIANO RAMOS; RODRIGO LABAT; FLÁVIO AIMBIRE S. CARVALHO; AIRTON BRANDÃO MARTIN; RODRIGO ÁLVARO B. LOPES-MARTINS. Efeito da administração oral de arginina sobre a pressão arterial e parâmetros cardíacos em ratos submetidos ao bloqueio crônico da síntese de óxido nítrico. Revista Brasileira de Medicina do Esporte, v. 12, n. 4, p. 169-174, 2006-08-00. (01/14384-8)

ANTONIO LUIZ MARTINS MAIA FILHO; FABRÍCIO PIRES DE MOURA DO AMARAL; AIRTON ABRAHÃO MARTIN; LUÍS EDUARDO SILVA SOARES. Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair. Brazilian Archives of Biology and Technology, v. 57, n. 3, p. 334-339, 2014-01-31. (01/14384-8)

ROSIA CESAR, ILENE CRISTINE; SILVA SOARES, LUIS EDUARDO; ALVES, LEANDRO PROCOPIO; MARTIN, AIRTON ABRAHAO; MUNIN, EGBERTO; SUZY LIPORONI, PRISCILA CHRISTIANE. Fourier Transform-Raman and Reflectance Studies on Dental Enamel Bleached with Hydrogen Peroxide Activated Using a Light-Emitting Diode-Laser System. Photomedicine and Laser Surgery, v. 27, n. 6, p. 913-919, DEC 2009. (01/14384-8)

ANA, P. A.; KAUFFMANN, C. M. F.; BACHMANN, L.; SOARES, L. E. S.; MARTIN, A. A.; GOMES, A. S. L.; ZEZELL, D. M.. FT-Raman spectroscopic analysis of Nd:YAG and Er, Cr:YSGG laser irradiated enamel for preventive purposes. Laser Physics, v. 24, n. 3, MAR 2014. (05/51689-2, 06/06746-0, 01/14384-8, 03/13489-6)

SILVA SOARES, LUIS EDUARDO; NAHORNY, SIDNEI; MARTIN, AIRTON ABRAHAO. FT-Raman Spectroscopy Study of Organic Matrix Degradation in Nanofilled Resin Composite. Microscopy and Microanalysis, v. 19, n. 2, p. 327-334, APR 2013. (01/14384-8, 07/07984-5)

DE SANT'ANNA, GISELLE RODRIGUES; PEREIRA DOS SANTOS, EDSON APARECIDO; SILVA SOARES, LUIS EDUARDO; DO ESPIRITO SANTO, ANA MARIA; MARTIN, AIRTON ABRAHAO; DUARTE, DANILO ANTONIO; PACHECO-SOARES, CRISTINA; BRUGNERA, JR., ALDO. Dental Enamel Irradiated with Infrared Diode Laser and Photoabsorbing Cream: Part 1-FT-Raman Study. Photomedicine and Laser Surgery, v. 27, n. 3, p. 499-507, JUN 2009. (01/14384-8)

CAVALLI, VANESSA; AZEVEDO RODRIGUES, LIDIANY KARLA; PAES-LEME, ADRIANA FRANCO; SILVA SOARES, LUIS EDUARDO; MARTIN, AIRTON ABRAHAO; BERGER, SANDRINE BITTENCOURT; GIANNINI, MARCELO. Effects of the Addition of Fluoride and Calcium to Low-Concentrated Carbamide Peroxide Agents on the Enamel Surface and Subsurface. Photomedicine and Laser Surgery, v. 29, n. 5, p. 319-325, MAY 2011. (01/14384-8, 03/07900-5)

MARTINHO, HERCULANO DA SILVA; DE OLIVEIRA MONTEIRO DA SILVA, CLAUDIA MARIA; BOTELHO MENDONCA YASSOYAMA, MARIA CHRISTINA; ANDRADE, PATRICIA DE OLIVEIRA; BITAR, RENATA ANDRADE; DO ESPIRITO SANTO, ANA MARIA; LOSCHIAVO ARISAWA, EMILIA ANGELA; MARTIN, AIRTON ABRAHAO. Role of cervicitis in the Raman-based optical diagnosis of cervical intraepithelial neoplasia. Journal of Biomedical Optics, v. 13, n. 5, SEP-OCT 2008. (01/14384-8)

SOARES‚ LES; LIPORONI‚ PCS; MARTIN‚ AA. The effect of soft-start polymerization by second generation LEDs on the degree of conversion of resin composite. Operative Dentistry, v. 32, n. 2, p. 160-165, 2007. (01/14384-8)

SILVA SOARES, LUIS EDUARDO; ANDRADE BITAR, RENATA; BRUGNERA JUNIOR, ALDO; ZANIN, A. A.; RESENDE, ERICK B. P. S.; JARA, WALTER A. A.; MARTIN, AIRTON A.; RECHMANN, P; FRIED, D. Er : YAG laser irradiation on dentin: FT-Raman and SEM studies. MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS, v. 6425, p. 5-pg., 2007-01-01. (01/14384-8)

SOARES, L. E. S.; CAMPOS, A. D. F.; MARTIN, A. A.. Human and Bovine Dentin Composition and Its Hybridization Mechanism Assessed by FT-Raman Spectroscopy. JOURNAL OF SPECTROSCOPY, v. 2013, p. 7-pg., 2013-01-01. (01/14384-8)

SILVA SOARES, LUIS EDUARDO; NAHORNY, SIDNEI; BRAGA, VIVIAN DE FARIA; MARCIANO, FERNANDA ROBERTA; BHATTACHARJEE, TANMOY T.; LOBO, ANDERSON OLIVEIRA. Raman spectroscopy-multivariate analysis related to morphological surface features on nanomaterials applied for dentin coverage. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 228, MAR 5 2020. (11/20345-7, 11/17877-7, 16/00575-1, 13/11192-8, 14/21587-2, 15/09697-0, 14/02163-7, 01/14384-8)

TOSATO, MAIRA G.; ALVES, RANI S.; DOS SANTOS, EDSON A. P.; RANIERO, LEANDRO; MENEZES, PRISCILA F. C.; BELLETTI, KLESIA M. S.; PRAES, CARLOS EDUARDO O.; MARTIN, AIRTON A.. Raman Spectroscopic Investigation of the Effects of Cosmetic Formulations on the Constituents and Properties of Human Skin. Photomedicine and Laser Surgery, v. 30, n. 2, p. 85-91, FEB 2012. (01/14384-8)

NAHORNY, SIDNEI; ZANIN, HUDSON; CHRISTINO, VINIE ABREU; MARCIANO, FERNANDA ROBERTA; OLIVEIRA LOBO, ANDERSON; SILVA SOARES, LUIS EDUARDO. Multi-walled carbon nanotubes/graphene oxide hybrid and nanohydroxyapatite composite: A novel coating to prevent dentin erosion. Materials Science & Engineering C-Materials for Biological Applications, v. 79, p. 199-208, OCT 1 2017. (14/21587-2, 01/14384-8, 11/17877-7, 11/20345-7, 15/50093-0, 13/20825-4, 14/02163-7, 15/09697-0, 13/11192-8, 16/00575-1)

PASCON, FERNANDA MIORI; KANTOVITZ, KAMILA ROSAMILIA; SILVA SOARES, LUIS EDUARDO; DO ESPIRITO SANTO, ANA MARIA; MARTIN, AIRTON ABRAHAO; PUPPIN-RONTANI, REGINA MARIA. Morphological and chemical changes in dentin after using endodontic agents: Fourier transform Raman spectroscopy, energy-dispersive x-ray fluorescence spectrometry, and scanning electron microscopy study. Journal of Biomedical Optics, v. 17, n. 7, JUL 2012. (01/14384-8, 05/58561-1)

LARISSA FERREIRA PACHECO; EFANI CAROLINE DE FREITAS BANZI; ELIANA RODRIGUES; LUIS EDUARDO SILVA SOARES; FERNANDA MIORI PASCON; LOURENCO CORRER-SOBRINHO; REGINA MARIA PUPPIN-RONTANI. Molecular and Structural Evaluation of Dentin Caries-Like Lesions Produced by Different Artificial Models. Brazilian Dental Journal, v. 24, n. 6, p. 610-618, 2013-12-00. (01/14384-8, 05/50811-9, 08/02331-6)

DE SANT'ANNA, GISELLE RODRIGUES; PEREIRA DOS SANTOS, EDSON APARECIDO; SILVA SOARES, LUIS EDUARDO; DO ESPIRITO SANTO, ANA MARIA; MARTIN, AIRTON ABRAHAO; DUARTE, DANILO ANTONIO; PACHECO-SOARES, CRISTINA; BRUGNERA, JR., ALDO. Dental Enamel Irradiated with Infrared Diode Laser and Photo-Absorbing Cream: Part 2-EDX Study. Photomedicine and Laser Surgery, v. 27, n. 5, p. 771-782, OCT 2009. (01/14384-8)

TEIXEIRA, CAROLINE S. B.; BITAR, RENATA A.; MARTINHO, HERCULANO S.; SANTOS, ANDRE B. O.; KULCSAR, MARCO A. V.; FRIGUGLIETTI, CELSO U. M.; DA COSTA, RICARDO B.; ARISAWA, EMILIA A. L.; MARTIN, AIRTON A.. Thyroid tissue analysis through Raman spectroscopy. ANALYST, v. 134, n. 11, p. 2361-2370, 2009. (01/14384-8)

SILVA SOARES, LUIS EDUARDO; DO ESPIRITO SANTO, ANA MARIA; BRUGNERA JUNIOR, ALDO; APARECIDA ZANIN, FATIMA ANTONIA; DA SILVA CARVALHO, CAROLINA; DE OLIVEIRA, RODRIGO; MARTIN, AIRTON ABRAHAO. Effects of Er:YAG laser irradiation and manipulation treatments on dentin components, part 1: Fourier transform-Raman study. Journal of Biomedical Optics, v. 14, n. 2, MAR-APR 2009. (01/14384-8)

PALMA‚ B.F.; FERRARI‚ A.B.; BITAR‚ R.A.; CARDOSO‚ M.A.; MARTIN‚ A.A.; DA SILVA MARTINHO‚ H.. DNA extraction systematics for spectroscopic studies. SENSORS, v. 8, n. 6, p. 3624-3632, 2008. (01/14384-8, 07/01622-4)

BITAR, RENATA ANDRADE; MARTINHO, HERCULANO DA SILVA; ZAMBELLI RAMALHO, LEANDRA NAIRA; DOS SANTOS JUNIOR, ARNALDO RODRIGUES; RAMALHO, FERNANDO SILVA; RANIERO, LEANDRO; MARTIN, AIRTON A.; MAHADEVANJANSEN, A; PETRICH, W. Study of aggressiveness prediction of mammary adenocarcinoma by Raman spectroscopy. BIOMEDICAL VIBRATIONAL SPECTROSCOPY V: ADVANCES IN RESEARCH AND INDUSTRY, v. 8219, p. 7-pg., 2012-01-01. (05/58565-7, 01/14384-8)

ANDRADE BITAR, RENATA; ANDRES AVENDANO JARA, WALTER; NETTO, MARIO M.; MARTINHO, HERCULANO; NAIRA ZAMBELLI RAMALHO, LEANDRA; ABRAHAO MARTIN, AIRTON; MAHADEVANJANSEN, A; PETRICH, WH. Study of human breast tissues biochemistry by FT-Raman spectroscopy. MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS, v. 6093, p. 10-pg., 2006-01-01. (01/14384-8)

BITAR, RENATA; MORENO, MARCELO; OLIVEIRA, ANDRA; CARTAXO, SIDNEY; MARTINHO, HERCULANO; SANTO, ANA MARIA DO ESPIRITO; SANTSS, IVAN DUNSHEE; FERREIRA, LYDIA MASSAKO; MARTIN, AIRTON; VODINH, T; et al. Raman spectra of pigmented skin conditions. MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS, v. 6430, p. 9-pg., 2007-01-01. (01/14384-8, 06/04931-5)

BITAR, R.; MARTINS, M. A.; RIBEIRO, D.; CARVALHO, C.; SANTOS, E. A. P.; RAMALHO, L. N. Z.; RAMALHO, F.; MARTINHO, H.; MARTIN, A. A.; MAHADEVANJANSEN, A; et al. In vivo Raman spectroscopy for breast cancer: diagnosis in animal model. MEDICAL IMAGING 2007: PACS AND IMAGING INFORMATICS, v. 6853, p. 7-pg., 2008-01-01. (05/58565-7, 01/14384-8)